Association of change in muscle mass assessed by D3-creatine dilution with changes in grip strength and walking speed

for the Osteoporotic Fractures in Men (MrOS) Study Research Group

Research output: Contribution to journalArticle

Abstract

Background: Muscle mass declines with age. However, common assessments used to quantify muscle mass are indirect. The D3-creatine (D3Cr) dilution method is a direct assessment of muscle mass; however, longitudinal changes have not been examined in relation to changes in other measures of muscle mass, strength, and performance. Methods: A convenience sample of 40 men from the Osteoporotic Fractures in Men Study (mean age = 83.3 years, standard deviation = 3.9) underwent repeat assessment of D3Cr muscle mass, dual-energy X-ray absorptiometry (DXA) lean mass, grip strength, and walking speed at two time points approximately 1.6 years apart (2014–2016). One-sample t-tests and Pearson correlations were used to examine changes in DXA total body lean mass, DXA appendicular lean mass/height2, DXA appendicular lean mass/weight, D3Cr muscle mass, D3Cr muscle mass/weight, grip strength, walking speed, and weight. Results: D3-creatine muscle mass, D3Cr muscle mass/weight, grip strength, and walking speed all significantly declined (all P < 0.01). The change in DXA measures of lean mass was moderately correlated with changes in D3Cr muscle mass. There was no significant correlation between the change in DXA measures of lean mass and change in walking speed (all P > 0.05). The change in D3Cr muscle mass/weight was moderately correlated with change in walking speed (r = 0.33, P <.05). The change in grip strength was weakly correlated with the change in DXA measures of lean mass and D3Cr muscle mass (r = 0.19–0.32). Conclusions: The results of our study provide new insights regarding the decline in muscle strength and D3Cr muscle mass. The D3Cr method may be a feasible tool to measure declines in muscle mass over time.

Original languageEnglish (US)
JournalJournal of Cachexia, Sarcopenia and Muscle
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Creatine
Hand Strength
Muscles
Photon Absorptiometry
Weights and Measures
Muscle Strength
Walking Speed
Osteoporotic Fractures

Keywords

  • Grip strength
  • Muscle mass
  • Sarcopenia
  • Walking speed

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Association of change in muscle mass assessed by D3-creatine dilution with changes in grip strength and walking speed. / for the Osteoporotic Fractures in Men (MrOS) Study Research Group.

In: Journal of Cachexia, Sarcopenia and Muscle, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Background: Muscle mass declines with age. However, common assessments used to quantify muscle mass are indirect. The D3-creatine (D3Cr) dilution method is a direct assessment of muscle mass; however, longitudinal changes have not been examined in relation to changes in other measures of muscle mass, strength, and performance. Methods: A convenience sample of 40 men from the Osteoporotic Fractures in Men Study (mean age = 83.3 years, standard deviation = 3.9) underwent repeat assessment of D3Cr muscle mass, dual-energy X-ray absorptiometry (DXA) lean mass, grip strength, and walking speed at two time points approximately 1.6 years apart (2014–2016). One-sample t-tests and Pearson correlations were used to examine changes in DXA total body lean mass, DXA appendicular lean mass/height2, DXA appendicular lean mass/weight, D3Cr muscle mass, D3Cr muscle mass/weight, grip strength, walking speed, and weight. Results: D3-creatine muscle mass, D3Cr muscle mass/weight, grip strength, and walking speed all significantly declined (all P < 0.01). The change in DXA measures of lean mass was moderately correlated with changes in D3Cr muscle mass. There was no significant correlation between the change in DXA measures of lean mass and change in walking speed (all P > 0.05). The change in D3Cr muscle mass/weight was moderately correlated with change in walking speed (r = 0.33, P <.05). The change in grip strength was weakly correlated with the change in DXA measures of lean mass and D3Cr muscle mass (r = 0.19–0.32). Conclusions: The results of our study provide new insights regarding the decline in muscle strength and D3Cr muscle mass. The D3Cr method may be a feasible tool to measure declines in muscle mass over time.",
keywords = "Grip strength, Muscle mass, Sarcopenia, Walking speed",
author = "{for the Osteoporotic Fractures in Men (MrOS) Study Research Group} and Duchowny, {Kate A.} and Peters, {Katherine E.} and Cummings, {Steven R.} and Orwoll, {Eric S.} and Hoffman, {Andrew R.} and Ensrud, {Kristine E.} and Cauley, {Jane A.} and Evans, {William J.} and Cawthon, {Peggy M.}",
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AU - for the Osteoporotic Fractures in Men (MrOS) Study Research Group

AU - Duchowny, Kate A.

AU - Peters, Katherine E.

AU - Cummings, Steven R.

AU - Orwoll, Eric S.

AU - Hoffman, Andrew R.

AU - Ensrud, Kristine E.

AU - Cauley, Jane A.

AU - Evans, William J.

AU - Cawthon, Peggy M.

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N2 - Background: Muscle mass declines with age. However, common assessments used to quantify muscle mass are indirect. The D3-creatine (D3Cr) dilution method is a direct assessment of muscle mass; however, longitudinal changes have not been examined in relation to changes in other measures of muscle mass, strength, and performance. Methods: A convenience sample of 40 men from the Osteoporotic Fractures in Men Study (mean age = 83.3 years, standard deviation = 3.9) underwent repeat assessment of D3Cr muscle mass, dual-energy X-ray absorptiometry (DXA) lean mass, grip strength, and walking speed at two time points approximately 1.6 years apart (2014–2016). One-sample t-tests and Pearson correlations were used to examine changes in DXA total body lean mass, DXA appendicular lean mass/height2, DXA appendicular lean mass/weight, D3Cr muscle mass, D3Cr muscle mass/weight, grip strength, walking speed, and weight. Results: D3-creatine muscle mass, D3Cr muscle mass/weight, grip strength, and walking speed all significantly declined (all P < 0.01). The change in DXA measures of lean mass was moderately correlated with changes in D3Cr muscle mass. There was no significant correlation between the change in DXA measures of lean mass and change in walking speed (all P > 0.05). The change in D3Cr muscle mass/weight was moderately correlated with change in walking speed (r = 0.33, P <.05). The change in grip strength was weakly correlated with the change in DXA measures of lean mass and D3Cr muscle mass (r = 0.19–0.32). Conclusions: The results of our study provide new insights regarding the decline in muscle strength and D3Cr muscle mass. The D3Cr method may be a feasible tool to measure declines in muscle mass over time.

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KW - Grip strength

KW - Muscle mass

KW - Sarcopenia

KW - Walking speed

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