Association between the PDGF receptor and members of the src family of tyrosine kinases

Robert M. Kypta; Yves Goldberg; Emin T. Ulug; Sara A. Courtneidge

doi:10.1016/0092-8674(90)90013-5

Association between the PDGF receptor and members of the src family of tyrosine kinases

Robert M. Kypta, Yves Goldberg, Emin T. Ulug, Sara A. Courtneidge

Cell, Developmental, & Cancer Biology

Research output: Contribution to journal › Article

463 Scopus citations

Abstract

We have examined the interaction between the plate-let-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60^c-src, p59^fyn, and pp62^c-yes. The kinase activities of all three enzymes were elevated after PDGF stimulation of quiescent fibroblasts, coincident with association of the src family kinases with the PDGF receptor and other proteins. The presence of a protein of 81-85 kd in these complexes correlated with the detection of phosphatidylinositol (PI) kinase activity (previously described to associate with both the PDGF receptor and pp60^c-src-middle T antigen). These results suggest that the physiological response to PDGF involves interaction of the receptor not only with serine/threonine and lipid kinases and a phospholipase, but also with other tyrosine kinases.

Original language	English (US)
Pages (from-to)	481-492
Number of pages	12
Journal	Cell
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/0092-8674(90)90013-5
State	Published - Aug 10 1990

Fingerprint

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kypta, R. M., Goldberg, Y., Ulug, E. T., & Courtneidge, S. A. (1990). Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell, 62(3), 481-492. https://doi.org/10.1016/0092-8674(90)90013-5

@article{724d6cc6d6444e1d85842c12dbf4ea39,

title = "Association between the PDGF receptor and members of the src family of tyrosine kinases",

abstract = "We have examined the interaction between the plate-let-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60c-src, p59fyn, and pp62c-yes. The kinase activities of all three enzymes were elevated after PDGF stimulation of quiescent fibroblasts, coincident with association of the src family kinases with the PDGF receptor and other proteins. The presence of a protein of 81-85 kd in these complexes correlated with the detection of phosphatidylinositol (PI) kinase activity (previously described to associate with both the PDGF receptor and pp60c-src-middle T antigen). These results suggest that the physiological response to PDGF involves interaction of the receptor not only with serine/threonine and lipid kinases and a phospholipase, but also with other tyrosine kinases.",

author = "Kypta, {Robert M.} and Yves Goldberg and Ulug, {Emin T.} and Courtneidge, {Sara A.}",

year = "1990",

month = aug

day = "10",

doi = "10.1016/0092-8674(90)90013-5",

language = "English (US)",

volume = "62",

pages = "481--492",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Association between the PDGF receptor and members of the src family of tyrosine kinases

AU - Kypta, Robert M.

AU - Goldberg, Yves

AU - Ulug, Emin T.

AU - Courtneidge, Sara A.

PY - 1990/8/10

Y1 - 1990/8/10

N2 - We have examined the interaction between the plate-let-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60c-src, p59fyn, and pp62c-yes. The kinase activities of all three enzymes were elevated after PDGF stimulation of quiescent fibroblasts, coincident with association of the src family kinases with the PDGF receptor and other proteins. The presence of a protein of 81-85 kd in these complexes correlated with the detection of phosphatidylinositol (PI) kinase activity (previously described to associate with both the PDGF receptor and pp60c-src-middle T antigen). These results suggest that the physiological response to PDGF involves interaction of the receptor not only with serine/threonine and lipid kinases and a phospholipase, but also with other tyrosine kinases.

AB - We have examined the interaction between the plate-let-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60c-src, p59fyn, and pp62c-yes. The kinase activities of all three enzymes were elevated after PDGF stimulation of quiescent fibroblasts, coincident with association of the src family kinases with the PDGF receptor and other proteins. The presence of a protein of 81-85 kd in these complexes correlated with the detection of phosphatidylinositol (PI) kinase activity (previously described to associate with both the PDGF receptor and pp60c-src-middle T antigen). These results suggest that the physiological response to PDGF involves interaction of the receptor not only with serine/threonine and lipid kinases and a phospholipase, but also with other tyrosine kinases.

UR - http://www.scopus.com/inward/record.url?scp=0025172811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025172811&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(90)90013-5

DO - 10.1016/0092-8674(90)90013-5

M3 - Article

C2 - 1696179

AN - SCOPUS:0025172811

VL - 62

SP - 481

EP - 492

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -

Access to Document

10.1016/0092-8674(90)90013-5