Association between the PDGF receptor and members of the src family of tyrosine kinases

Robert M. Kypta; Yves Goldberg; Emin T. Ulug; Sara A. Courtneidge

doi:10.1016/0092-8674(90)90013-5

Association between the PDGF receptor and members of the src family of tyrosine kinases

Robert M. Kypta, Yves Goldberg, Emin T. Ulug, Sara A. Courtneidge

Cell, Developmental, & Cancer Biology

Research output: Contribution to journal › Article › peer-review

470 Scopus citations

Abstract

We have examined the interaction between the plate-let-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60^c-src, p59^fyn, and pp62^c-yes. The kinase activities of all three enzymes were elevated after PDGF stimulation of quiescent fibroblasts, coincident with association of the src family kinases with the PDGF receptor and other proteins. The presence of a protein of 81-85 kd in these complexes correlated with the detection of phosphatidylinositol (PI) kinase activity (previously described to associate with both the PDGF receptor and pp60^c-src-middle T antigen). These results suggest that the physiological response to PDGF involves interaction of the receptor not only with serine/threonine and lipid kinases and a phospholipase, but also with other tyrosine kinases.

Original language	English (US)
Pages (from-to)	481-492
Number of pages	12
Journal	Cell
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/0092-8674(90)90013-5
State	Published - Aug 10 1990

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "We have examined the interaction between the plate-let-derived growth factor (PDGF) receptor and three src family tyrosine kinases, pp60c-src, p59fyn, and pp62c-yes. The kinase activities of all three enzymes were elevated after PDGF stimulation of quiescent fibroblasts, coincident with association of the src family kinases with the PDGF receptor and other proteins. The presence of a protein of 81-85 kd in these complexes correlated with the detection of phosphatidylinositol (PI) kinase activity (previously described to associate with both the PDGF receptor and pp60c-src-middle T antigen). These results suggest that the physiological response to PDGF involves interaction of the receptor not only with serine/threonine and lipid kinases and a phospholipase, but also with other tyrosine kinases.",

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