Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus

Christine Lee, Edward J. Boyko, Elsa S. Strotmeyer, Cora E. Lewis, Peggy Mannen Cawthon, Andrew R. Hoffman, Susan A. Everson-Rose, Elizabeth Barrett-Connor, Eric Orwoll

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

OBJECTIVES: To examine the associations between insulin resistance and changes in body composition in older men without diabetes mellitus. DESIGN: Longitudinal cohort study of older men participating in the Osteoporotic Fractures in Men (MrOS) study. SETTING: Six U.S. clinical centers. PARTICIPANTS: Three thousand one hundred thirty-two ambulatory men aged 65 and older at baseline. MEASUREMENTS: Baseline insulin resistance was calculated for men without diabetes mellitus using the homeostasis model assessment of insulin resistance (HOMA-IR). Total lean, appendicular lean, total fat, and truncal fat mass were measured using dual energy X-ray absorptiometry scans at baseline and 4.6 ± 0.3 years later in 3,132 men with HOMA-IR measurements. RESULTS: There was greater loss of weight, total lean mass, and appendicular lean mass and less gain in total fat mass and truncal fat mass with increasing quartiles of HOMA-IR (P

Original languageEnglish (US)
Pages (from-to)1217-1224
Number of pages8
JournalJournal of the American Geriatrics Society
Volume59
Issue number7
DOIs
StatePublished - Jul 2011

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Insulin Resistance
Diabetes Mellitus
Fats
Homeostasis
Osteoporotic Fractures
Photon Absorptiometry
Body Composition
Longitudinal Studies
Weight Loss
Cohort Studies

Keywords

  • body composition
  • fat mass
  • insulin resistance
  • lean mass
  • older men

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus. / Lee, Christine; Boyko, Edward J.; Strotmeyer, Elsa S.; Lewis, Cora E.; Cawthon, Peggy Mannen; Hoffman, Andrew R.; Everson-Rose, Susan A.; Barrett-Connor, Elizabeth; Orwoll, Eric.

In: Journal of the American Geriatrics Society, Vol. 59, No. 7, 07.2011, p. 1217-1224.

Research output: Contribution to journalArticle

Lee, C, Boyko, EJ, Strotmeyer, ES, Lewis, CE, Cawthon, PM, Hoffman, AR, Everson-Rose, SA, Barrett-Connor, E & Orwoll, E 2011, 'Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus', Journal of the American Geriatrics Society, vol. 59, no. 7, pp. 1217-1224. https://doi.org/10.1111/j.1532-5415.2011.03472.x
Lee, Christine ; Boyko, Edward J. ; Strotmeyer, Elsa S. ; Lewis, Cora E. ; Cawthon, Peggy Mannen ; Hoffman, Andrew R. ; Everson-Rose, Susan A. ; Barrett-Connor, Elizabeth ; Orwoll, Eric. / Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus. In: Journal of the American Geriatrics Society. 2011 ; Vol. 59, No. 7. pp. 1217-1224.
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