Association Between Adiposity and Left Ventricular Mass in Children With Hypertension

Tammy M. Brady, Lawrence J. Appel, Kathryn Holmes, Barbara Fivush, Edgar R. Miller

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalJournal of Clinical Hypertension
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Adiposity
Left Ventricular Hypertrophy
Hypertension
Blood Pressure
Aldosterone
Body Mass Index
Cohort Studies
Cardiovascular Diseases
Obesity
Prospective Studies
Weights and Measures
Serum
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Association Between Adiposity and Left Ventricular Mass in Children With Hypertension. / Brady, Tammy M.; Appel, Lawrence J.; Holmes, Kathryn; Fivush, Barbara; Miller, Edgar R.

In: Journal of Clinical Hypertension, Vol. 18, No. 7, 01.07.2016, p. 625-633.

Research output: Contribution to journalArticle

Brady, Tammy M. ; Appel, Lawrence J. ; Holmes, Kathryn ; Fivush, Barbara ; Miller, Edgar R. / Association Between Adiposity and Left Ventricular Mass in Children With Hypertension. In: Journal of Clinical Hypertension. 2016 ; Vol. 18, No. 7. pp. 625-633.
@article{c78475e566e6453d895526717e4fca50,
title = "Association Between Adiposity and Left Ventricular Mass in Children With Hypertension",
abstract = "Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51{\%} were overweight/obese and 41{\%} had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.",
author = "Brady, {Tammy M.} and Appel, {Lawrence J.} and Kathryn Holmes and Barbara Fivush and Miller, {Edgar R.}",
year = "2016",
month = "7",
day = "1",
doi = "10.1111/jch.12717",
language = "English (US)",
volume = "18",
pages = "625--633",
journal = "Journal of Clinical Hypertension",
issn = "1524-6175",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Association Between Adiposity and Left Ventricular Mass in Children With Hypertension

AU - Brady, Tammy M.

AU - Appel, Lawrence J.

AU - Holmes, Kathryn

AU - Fivush, Barbara

AU - Miller, Edgar R.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.

AB - Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.

UR - http://www.scopus.com/inward/record.url?scp=84978842570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978842570&partnerID=8YFLogxK

U2 - 10.1111/jch.12717

DO - 10.1111/jch.12717

M3 - Article

C2 - 26530452

AN - SCOPUS:84978842570

VL - 18

SP - 625

EP - 633

JO - Journal of Clinical Hypertension

JF - Journal of Clinical Hypertension

SN - 1524-6175

IS - 7

ER -