@article{c78475e566e6453d895526717e4fca50,
title = "Association Between Adiposity and Left Ventricular Mass in Children With Hypertension",
abstract = "Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.",
author = "Brady, {Tammy M.} and Appel, {Lawrence J.} and Holmes, {Kathryn W.} and Barbara Fivush and Miller, {Edgar R.}",
note = "Funding Information: We would like to thank Sara Boynton, BA, and Sanjay Jumani, BA, who conducted the data collection that made this study possible. Neither of these individuals have any conflicts of interest to disclose. The authors have no conflicts of interest to report. This study is supported by grants from the American Society of Nephrology, National Kidney Foundation of MD, American Heart Association, Thomas Wilson Sanitarium for Children of Baltimore City, and the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (K23HL119622) and was also made possible by grant number UL1 RR 025005 from the National Center for Research Resources (NCRR), a component of the NIH, and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NCRR or NIH. None of the sponsors had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript. The first draft of this manuscript was written by Tammy M. Brady and there was no honorarium, grant, or other form of payment given to anyone to produce the manuscript. Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2016",
month = jul,
day = "1",
doi = "10.1111/jch.12717",
language = "English (US)",
volume = "18",
pages = "625--633",
journal = "Journal of Clinical Hypertension",
issn = "1524-6175",
publisher = "Wiley-Blackwell",
number = "7",
}