Abstract
Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 625-633 |
| Number of pages | 9 |
| Journal | Journal of Clinical Hypertension |
| Volume | 18 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2016 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Association Between Adiposity and Left Ventricular Mass in Children With Hypertension. / Brady, Tammy M.; Appel, Lawrence J.; Holmes, Kathryn; Fivush, Barbara; Miller, Edgar R.
In: Journal of Clinical Hypertension, Vol. 18, No. 7, 01.07.2016, p. 625-633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association Between Adiposity and Left Ventricular Mass in Children With Hypertension
AU - Brady, Tammy M.
AU - Appel, Lawrence J.
AU - Holmes, Kathryn
AU - Fivush, Barbara
AU - Miller, Edgar R.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.
AB - Left ventricular hypertrophy (LVH) is prevalent among hypertensive children; however, blood pressure (BP) does not predict its presence. The authors conducted a 1-year prospective cohort study to examine the hypothesis that obesity-related risk factors are associated with left ventricular mass index (LVMI) in hypertensive children, and the association between adiposity and LVMI is mediated by BP-dependent and -independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow-up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m2.7 vs 0.95 g/m2.7. Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P=.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI.
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UR - http://www.scopus.com/inward/citedby.url?scp=84978842570&partnerID=8YFLogxK
U2 - 10.1111/jch.12717
DO - 10.1111/jch.12717
M3 - Article
C2 - 26530452
AN - SCOPUS:84978842570
VL - 18
SP - 625
EP - 633
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
SN - 1524-6175
IS - 7
ER -