Assessment of the effects of dipyridamole and dobutamine on coronary microcirculation using myocardial contrast echocardiography

J. Bin, Kevin Wei, R. A. Pelberg

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To evaluate the effects of dipyridamole and dobutamine on myocardial blood flow (MBF) and myocardial blood volume (MBV), and their ability to detect non-flow-limiting coronary stenoses with myocardial contrast echocardiography (MCE). METHODS: Thirteen closed-chest dogs were studied at 7-10 days after placement of ameroid constrictors around proximal coronary arteries and their branches. MBF was measured with radiolabeled microspheres and myocardial plateau video intensity (VI, which indicates relative MBV) and microbubble velocity (beta) were measured with MCE at rest, after dipyridamole (0.56 mg/kg), and during peak dobutamine dose (30-40 micrograms.kg-1.min-1). RESULTS: The effects of both agents on MBF were similar in abnormal and normal segments. Plateau VI increased more and beta increased less with dobutamine than dipyridamole (P <0.05), but the plateau VI ratios and beta ratios between abnormal and normal segments were almost identical during both drugs (P <NS), resulting in similar perfusion defects. Excellent linear relations were found between the plateau VI ratio or beta ratio and MBF (derived from radiolabeled microspheres) ratio from abnormal and normal beds during dipyridamole and dobutamine. CONCLUSION: Although the effect of dipyridamole and dobutamine on MBV is different, they unmask MBF reserve to a similar extent. Thus, the quantification of stenosis severity is identical using both agents with MCE.

Original languageEnglish (US)
Pages (from-to)939-942
Number of pages4
JournalZhonghua yi xue za zhi
Volume80
Issue number12
StatePublished - Dec 2000
Externally publishedYes

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Dobutamine
Dipyridamole
Microcirculation
Echocardiography
Blood Volume
Microspheres
Microbubbles
Coronary Stenosis
Coronary Vessels
Pathologic Constriction
Thorax
Perfusion
Dogs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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Assessment of the effects of dipyridamole and dobutamine on coronary microcirculation using myocardial contrast echocardiography. / Bin, J.; Wei, Kevin; Pelberg, R. A.

In: Zhonghua yi xue za zhi, Vol. 80, No. 12, 12.2000, p. 939-942.

Research output: Contribution to journalArticle

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