Assessment of Orbital Computed Tomography (CT) Imaging Biomarkers in Patients with Thyroid Eye Disease

Shikha Chaganti, Kevin Mundy, Michael P. DeLisi, Katrina M. Nelson, Robert L. Harrigan, Robert L. Galloway, Bennett A. Landman, Louise A. Mawn

Research output: Contribution to journalArticle

Abstract

To understand potential orbital biomarkers generated from computed tomography (CT) imaging in patients with thyroid eye disease. This is a retrospective cohort study. From a database of an ongoing thyroid eye disease research study at our institution, we identified 85 subjects who had both clinical examination and laboratory records supporting the diagnosis of thyroid eye disease and concurrent imaging prior to any medical or surgical intervention. Patients were excluded if imaging quality or type was not amenable to segmentation. The images of 170 orbits were analyzed with the developed automated segmentation tool. The main outcome measure was to cross 25 CT structural metrics for each eye with nine clinical markers using a Kendall rank correlation test to identify significant relationships. The Kendall rank correlation test between automatically calculated CT metrics and clinical data demonstrated numerous correlations. Extraocular rectus muscle metrics, such as the average diameter of the superior, medial, and lateral rectus muscles, showed a strong correlation (p < 0.05) with loss of visual acuity and presence of ocular motility defects. Hertel measurements demonstrated a strong correlation (p < 0.05) with volumetric measurements of the optic nerve and other orbital metrics such as the crowding index and proptosis. Optic neuropathy was strongly correlated (p < 0.05) with an increase in the maximum diameter of the superior muscle. This novel method of automated imaging metrics may provide objective, rapid clinical information. This data may be useful for appreciation of severity of thyroid eye disease and recognition of risk factors of visual impairment from dysthyroid optic neuropathy from CT imaging.

Original languageEnglish (US)
JournalJournal of Digital Imaging
DOIs
StatePublished - Jan 1 2019

Fingerprint

Eye Diseases
Thyroid Diseases
Biomarkers
Tomography
Imaging techniques
Optic Nerve Diseases
Muscle
Optics
Oculomotor Muscles
Muscles
Crowding
Exophthalmos
Vision Disorders
Orbit
Optic Nerve
Visual Acuity
Cohort Studies
Retrospective Studies
Outcome Assessment (Health Care)
Databases

Keywords

  • CT
  • Multi-atlas
  • Optic nerve
  • Thyroid eye disease

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Science Applications

Cite this

Assessment of Orbital Computed Tomography (CT) Imaging Biomarkers in Patients with Thyroid Eye Disease. / Chaganti, Shikha; Mundy, Kevin; DeLisi, Michael P.; Nelson, Katrina M.; Harrigan, Robert L.; Galloway, Robert L.; Landman, Bennett A.; Mawn, Louise A.

In: Journal of Digital Imaging, 01.01.2019.

Research output: Contribution to journalArticle

Chaganti, Shikha ; Mundy, Kevin ; DeLisi, Michael P. ; Nelson, Katrina M. ; Harrigan, Robert L. ; Galloway, Robert L. ; Landman, Bennett A. ; Mawn, Louise A. / Assessment of Orbital Computed Tomography (CT) Imaging Biomarkers in Patients with Thyroid Eye Disease. In: Journal of Digital Imaging. 2019.
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