Assessment of atherosclerosis in chronic granulomatous disease

Christopher Sibley, Tyra Estwick, Anna Zavodni, Chiung Yu Huang, Alan C. Kwan, Benjamin P. Soule, Debra A Long Priel, Alan T. Remaley, Amanda K Rudman Spergel, Evrim B. Turkbey, Douglas B. Kuhns, Steven M. Holland, Harry L. Malech, Kol A. Zarember, David A. Bluemke, John I. Gallin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background-Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates. This may result in a reduction in atherosclerotic injury.

Methods and Results-We prospectively assessed the prevalence of cardiovascular risk factors, biomarkers of inflammation and neutrophil activation, and the presence of magnetic resonance imaging and computed tomography quantified subclinical atherosclerosis in the carotid and coronary arteries of 41 patients with CGD and 25 healthy controls in the same age range. Univariable and multivariable associations among risk factors, inflammatory markers, and atherosclerosis burden were assessed. Patients with CGD had significant elevations in traditional risk factors and inflammatory markers compared with control subjects, including hypertension, high-sensitivity C-reactive protein, oxidized low-density lipoprotein, and low high-density lipoprotein. Despite this, patients with CGD had a 22% lower internal carotid artery wall volume compared with control subjects (361.3±76.4 mm3 versus 463.5±104.7 mm3; P

Conclusions-The observation by magnetic resonance imaging and computerized tomography of reduced carotid but not coronary artery atherosclerosis in patients with CGD despite the high prevalence of traditional risk factors raises questions about the role of NADPH oxidase in the pathogenesis of clinically significant atherosclerosis. Additional high-resolution studies in multiple vascular beds are required to address the therapeutic potential of NADPH oxidase inhibition in cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)2031-2039
Number of pages9
JournalCirculation
Volume130
Issue number23
DOIs
StatePublished - Dec 2 2014
Externally publishedYes

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Chronic Granulomatous Disease
Atherosclerosis
NADPH Oxidase
Coronary Vessels
Tomography
Magnetic Resonance Imaging
Neutrophil Activation
Internal Carotid Artery
HDL Lipoproteins
Phagocytes
LDL Lipoproteins
Carotid Arteries
C-Reactive Protein
Blood Vessels
Coronary Artery Disease
Cardiovascular Diseases
Biomarkers
Observation
Oxygen
Hypertension

Keywords

  • Atherosclerosis
  • Carotid arteries
  • Coronary vessels
  • Immune system
  • Inflammation

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Sibley, C., Estwick, T., Zavodni, A., Huang, C. Y., Kwan, A. C., Soule, B. P., ... Gallin, J. I. (2014). Assessment of atherosclerosis in chronic granulomatous disease. Circulation, 130(23), 2031-2039. https://doi.org/10.1161/CIRCULATIONAHA.113.006824

Assessment of atherosclerosis in chronic granulomatous disease. / Sibley, Christopher; Estwick, Tyra; Zavodni, Anna; Huang, Chiung Yu; Kwan, Alan C.; Soule, Benjamin P.; Priel, Debra A Long; Remaley, Alan T.; Spergel, Amanda K Rudman; Turkbey, Evrim B.; Kuhns, Douglas B.; Holland, Steven M.; Malech, Harry L.; Zarember, Kol A.; Bluemke, David A.; Gallin, John I.

In: Circulation, Vol. 130, No. 23, 02.12.2014, p. 2031-2039.

Research output: Contribution to journalArticle

Sibley, C, Estwick, T, Zavodni, A, Huang, CY, Kwan, AC, Soule, BP, Priel, DAL, Remaley, AT, Spergel, AKR, Turkbey, EB, Kuhns, DB, Holland, SM, Malech, HL, Zarember, KA, Bluemke, DA & Gallin, JI 2014, 'Assessment of atherosclerosis in chronic granulomatous disease', Circulation, vol. 130, no. 23, pp. 2031-2039. https://doi.org/10.1161/CIRCULATIONAHA.113.006824
Sibley C, Estwick T, Zavodni A, Huang CY, Kwan AC, Soule BP et al. Assessment of atherosclerosis in chronic granulomatous disease. Circulation. 2014 Dec 2;130(23):2031-2039. https://doi.org/10.1161/CIRCULATIONAHA.113.006824
Sibley, Christopher ; Estwick, Tyra ; Zavodni, Anna ; Huang, Chiung Yu ; Kwan, Alan C. ; Soule, Benjamin P. ; Priel, Debra A Long ; Remaley, Alan T. ; Spergel, Amanda K Rudman ; Turkbey, Evrim B. ; Kuhns, Douglas B. ; Holland, Steven M. ; Malech, Harry L. ; Zarember, Kol A. ; Bluemke, David A. ; Gallin, John I. / Assessment of atherosclerosis in chronic granulomatous disease. In: Circulation. 2014 ; Vol. 130, No. 23. pp. 2031-2039.
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AU - Estwick, Tyra

AU - Zavodni, Anna

AU - Huang, Chiung Yu

AU - Kwan, Alan C.

AU - Soule, Benjamin P.

AU - Priel, Debra A Long

AU - Remaley, Alan T.

AU - Spergel, Amanda K Rudman

AU - Turkbey, Evrim B.

AU - Kuhns, Douglas B.

AU - Holland, Steven M.

AU - Malech, Harry L.

AU - Zarember, Kol A.

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