Assembly of hair bundles, an amazing problem for cell biology

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

The hair bundle-the sensory organelle of inner-ear hair cells of vertebrates-exemplifies the ability of a cell to assemble complex, elegant structures. Proper construction of the bundle is required for proper mechanotransduction in response to external forces and to transmit information about sound and movement. Bundles contain tightly controlled numbers of actin-filled stereocilia, which are arranged in defined rows of precise heights. Indeed, many deafness mutations that disable hair-cell cytoskeletal proteins also disrupt bundles. Bundle assembly is a tractable problem in molecular and cellular systems biology; the sequence of structural changes in stereocilia is known, and a modest number of proteins may be involved.

Original languageEnglish (US)
Pages (from-to)2727-2732
Number of pages6
JournalMolecular biology of the cell
Volume26
Issue number15
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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