Assembly of hair bundles, an amazing problem for cell biology

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The hair bundle-the sensory organelle of inner-ear hair cells of vertebrates-exemplifies the ability of a cell to assemble complex, elegant structures. Proper construction of the bundle is required for proper mechanotransduction in response to external forces and to transmit information about sound and movement. Bundles contain tightly controlled numbers of actin-filled stereocilia, which are arranged in defined rows of precise heights. Indeed, many deafness mutations that disable hair-cell cytoskeletal proteins also disrupt bundles. Bundle assembly is a tractable problem in molecular and cellular systems biology; the sequence of structural changes in stereocilia is known, and a modest number of proteins may be involved.

Original languageEnglish (US)
Pages (from-to)2727-2732
Number of pages6
JournalMolecular Biology of the Cell
Volume26
Issue number15
DOIs
StatePublished - Aug 1 2015

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Stereocilia
Inner Auditory Hair Cells
Cell Biology
Cytoskeletal Proteins
Systems Biology
Deafness
Inner Ear
Organelles
Vertebrates
Actins
Mutation
Proteins
isofenphos

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Assembly of hair bundles, an amazing problem for cell biology. / Barr-Gillespie, Peter.

In: Molecular Biology of the Cell, Vol. 26, No. 15, 01.08.2015, p. 2727-2732.

Research output: Contribution to journalArticle

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