Aqueous humor outflow: What do we know? Where will it lead us?

Michael P. Fautsch; Douglas H. Johnson; Ted S. Acott; Makoto Aihara; Sanjoy K. Bhattacharya; Terete Borrás; Carl B. Camras; Mortimer M. Civan; Abbot F. Clark; Craig E. Crosson; Jonathan G. Crowston; David Epstein; C. Ross Ethier; Thomas F. Freddo; Haiyan Gong; Pedro Gonzalez; Simon W. John; Mark Johnson; Paul L. Kaufman; Paul A. Knepper; James D. Lindsey; Elke Lütjen-Drecoll; Donna M. Peters; P. Vasantha Rao; Sayon Roy; Paul Russell; Daniel Stamer; Ernst R. Tamm; Carol B. Toris; Robert N. Weinreb; Beatrice Yue; Paul Bornstein; Peter F. Davies; Benjamin Geiger; Dontscho Kerjaschki; James Mitchell; Eveline Schneeberger; Alan Stitt; David C. Zawieja; Charles Bosworth; John Grunden; Elizabeth Kim; Casey Kopczynski; Achim Krauss; Noorjahan Panjwani; Christopher Paterson; Granesh Prasanna; Douglas Rhee; Andy Whitlock; Darrell WuDunn

doi:10.1167/iovs.06-0830

Aqueous humor outflow: What do we know? Where will it lead us?

Michael P. Fautsch, Douglas H. Johnson, Ted S. Acott, Makoto Aihara, Sanjoy K. Bhattacharya, Terete Borrás, Carl B. Camras, Mortimer M. Civan, Abbot F. Clark, Craig E. Crosson, Jonathan G. Crowston, David Epstein, C. Ross Ethier, Thomas F. Freddo, Haiyan Gong, Pedro Gonzalez, Simon W. John, Mark Johnson, Paul L. Kaufman, Paul A. KnepperJames D. Lindsey, Elke Lütjen-Drecoll, Donna M. Peters, P. Vasantha Rao, Sayon Roy, Paul Russell, Daniel Stamer, Ernst R. Tamm, Carol B. Toris, Robert N. Weinreb, Beatrice Yue, Paul Bornstein, Peter F. Davies, Benjamin Geiger, Dontscho Kerjaschki, James Mitchell, Eveline Schneeberger, Alan Stitt, David C. Zawieja, Charles Bosworth, John Grunden, Elizabeth Kim, Casey Kopczynski, Achim Krauss, Noorjahan Panjwani, Christopher Paterson, Granesh Prasanna, Douglas Rhee, Andy Whitlock, Darrell WuDunn

Ophthalmology

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Many questions remain in the study of the normal aqueous outflow pathway and understanding of what is altered in POAG. One of the goals of the conference was to identify future areas of study that will improve our understanding of aqueous humor outflow. These questions have been summarized in Table 1. Finally, suggestions were made that the role of ARVO in research could be expanded in developing a consensus on terminology and techniques. "Giant vacuoles" of Schlemm's canal endothelium are not truly intracytoplasmic vacuoles, and the term and concept was initially confusing to the outside scientists at the conference. An ARVO consensus committee could resolve such issues. Similarly, should a consensus be reached on standard culture conditions for trabecular or Schlemm's canal cells? At present the comparisons of results from different laboratories can be difficult because of differences in culture media, serum supplements, and other culture conditions.

Original language	English (US)
Pages (from-to)	4181-4187
Number of pages	7
Journal	Investigative Ophthalmology and Visual Science
Volume	47
Issue number	10
DOIs	https://doi.org/10.1167/iovs.06-0830
State	Published - Oct 2006

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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Fautsch, M. P., Johnson, D. H., Acott, T. S., Aihara, M., Bhattacharya, S. K., Borrás, T., Camras, C. B., Civan, M. M., Clark, A. F., Crosson, C. E., Crowston, J. G., Epstein, D., Ethier, C. R., Freddo, T. F., Gong, H., Gonzalez, P., John, S. W., Johnson, M., Kaufman, P. L., ... WuDunn, D. (2006). Aqueous humor outflow: What do we know? Where will it lead us? Investigative Ophthalmology and Visual Science, 47(10), 4181-4187. https://doi.org/10.1167/iovs.06-0830

Fautsch, MP, Johnson, DH, Acott, TS, Aihara, M, Bhattacharya, SK, Borrás, T, Camras, CB, Civan, MM, Clark, AF, Crosson, CE, Crowston, JG, Epstein, D, Ethier, CR, Freddo, TF, Gong, H, Gonzalez, P, John, SW, Johnson, M, Kaufman, PL, Knepper, PA, Lindsey, JD, Lütjen-Drecoll, E, Peters, DM, Rao, PV, Roy, S, Russell, P, Stamer, D, Tamm, ER, Toris, CB, Weinreb, RN, Yue, B, Bornstein, P, Davies, PF, Geiger, B, Kerjaschki, D, Mitchell, J, Schneeberger, E, Stitt, A, Zawieja, DC, Bosworth, C, Grunden, J, Kim, E, Kopczynski, C, Krauss, A, Panjwani, N, Paterson, C, Prasanna, G, Rhee, D, Whitlock, A & WuDunn, D 2006, 'Aqueous humor outflow: What do we know? Where will it lead us?', Investigative Ophthalmology and Visual Science, vol. 47, no. 10, pp. 4181-4187. https://doi.org/10.1167/iovs.06-0830

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abstract = "Many questions remain in the study of the normal aqueous outflow pathway and understanding of what is altered in POAG. One of the goals of the conference was to identify future areas of study that will improve our understanding of aqueous humor outflow. These questions have been summarized in Table 1. Finally, suggestions were made that the role of ARVO in research could be expanded in developing a consensus on terminology and techniques. {"}Giant vacuoles{"} of Schlemm's canal endothelium are not truly intracytoplasmic vacuoles, and the term and concept was initially confusing to the outside scientists at the conference. An ARVO consensus committee could resolve such issues. Similarly, should a consensus be reached on standard culture conditions for trabecular or Schlemm's canal cells? At present the comparisons of results from different laboratories can be difficult because of differences in culture media, serum supplements, and other culture conditions.",

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AU - Fautsch, Michael P.

AU - Johnson, Douglas H.

AU - Acott, Ted S.

AU - Aihara, Makoto

AU - Bhattacharya, Sanjoy K.

AU - Borrás, Terete

AU - Camras, Carl B.

AU - Civan, Mortimer M.

AU - Clark, Abbot F.

AU - Crosson, Craig E.

AU - Crowston, Jonathan G.

AU - Epstein, David

AU - Ethier, C. Ross

AU - Freddo, Thomas F.

AU - Gong, Haiyan

AU - Gonzalez, Pedro

AU - John, Simon W.

AU - Johnson, Mark

AU - Kaufman, Paul L.

AU - Knepper, Paul A.

AU - Lindsey, James D.

AU - Lütjen-Drecoll, Elke

AU - Peters, Donna M.

AU - Rao, P. Vasantha

AU - Roy, Sayon

AU - Russell, Paul

AU - Stamer, Daniel

AU - Tamm, Ernst R.

AU - Toris, Carol B.

AU - Weinreb, Robert N.

AU - Yue, Beatrice

AU - Bornstein, Paul

AU - Davies, Peter F.

AU - Geiger, Benjamin

AU - Kerjaschki, Dontscho

AU - Mitchell, James

AU - Schneeberger, Eveline

AU - Stitt, Alan

AU - Zawieja, David C.

AU - Bosworth, Charles

AU - Grunden, John

AU - Kim, Elizabeth

AU - Kopczynski, Casey

AU - Krauss, Achim

AU - Panjwani, Noorjahan

AU - Paterson, Christopher

AU - Prasanna, Granesh

AU - Rhee, Douglas

AU - Whitlock, Andy

AU - WuDunn, Darrell

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Aqueous humor outflow: What do we know? Where will it lead us?

Abstract

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