Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand, Laura E. Waggoner, Grace E. Lim, Katherine H. Sharp, Christian P. Ridley, Margo Haygood

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

Original languageEnglish (US)
Pages (from-to)122-142
Number of pages21
JournalNatural Product Reports
Volume21
Issue number1
DOIs
StatePublished - Feb 2004
Externally publishedYes

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Symbiosis
Invertebrates
Metabolites
Clone Cells
Genes

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Hildebrand, M., Waggoner, L. E., Lim, G. E., Sharp, K. H., Ridley, C. P., & Haygood, M. (2004). Approaches to identify, clone, and express symbiont bioactive metabolite genes. Natural Product Reports, 21(1), 122-142. https://doi.org/10.1039/b302336m

Approaches to identify, clone, and express symbiont bioactive metabolite genes. / Hildebrand, Mark; Waggoner, Laura E.; Lim, Grace E.; Sharp, Katherine H.; Ridley, Christian P.; Haygood, Margo.

In: Natural Product Reports, Vol. 21, No. 1, 02.2004, p. 122-142.

Research output: Contribution to journalArticle

Hildebrand, M, Waggoner, LE, Lim, GE, Sharp, KH, Ridley, CP & Haygood, M 2004, 'Approaches to identify, clone, and express symbiont bioactive metabolite genes', Natural Product Reports, vol. 21, no. 1, pp. 122-142. https://doi.org/10.1039/b302336m
Hildebrand M, Waggoner LE, Lim GE, Sharp KH, Ridley CP, Haygood M. Approaches to identify, clone, and express symbiont bioactive metabolite genes. Natural Product Reports. 2004 Feb;21(1):122-142. https://doi.org/10.1039/b302336m
Hildebrand, Mark ; Waggoner, Laura E. ; Lim, Grace E. ; Sharp, Katherine H. ; Ridley, Christian P. ; Haygood, Margo. / Approaches to identify, clone, and express symbiont bioactive metabolite genes. In: Natural Product Reports. 2004 ; Vol. 21, No. 1. pp. 122-142.
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