Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand, Laura E. Waggoner, Grace E. Lim, Katherine H. Sharp, Christian P. Ridley, Margo G. Haygood

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

Original languageEnglish (US)
Pages (from-to)122-142
Number of pages21
JournalNatural Product Reports
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2004

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Hildebrand, M., Waggoner, L. E., Lim, G. E., Sharp, K. H., Ridley, C. P., & Haygood, M. G. (2004). Approaches to identify, clone, and express symbiont bioactive metabolite genes. Natural Product Reports, 21(1), 122-142. https://doi.org/10.1039/b302336m