Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand; Laura E. Waggoner; Grace E. Lim; Katherine H. Sharp; Christian P. Ridley; Margo G. Haygood

doi:10.1039/b302336m

Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand, Laura E. Waggoner, Grace E. Lim, Katherine H. Sharp, Christian P. Ridley, Margo G. Haygood

Center for Coastal Margins

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

Original language	English (US)
Pages (from-to)	122-142
Number of pages	21
Journal	Natural Product Reports
Volume	21
Issue number	1
DOIs	https://doi.org/10.1039/b302336m
State	Published - Feb 2004

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1039/b302336m

Cite this

@article{c484d05af6484832b4f04922e397a4c1,

title = "Approaches to identify, clone, and express symbiont bioactive metabolite genes",

abstract = "This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.",

author = "Mark Hildebrand and Waggoner, {Laura E.} and Lim, {Grace E.} and Sharp, {Katherine H.} and Ridley, {Christian P.} and Haygood, {Margo G.}",

year = "2004",

month = feb,

doi = "10.1039/b302336m",

language = "English (US)",

volume = "21",

pages = "122--142",

journal = "Natural Product Reports",

issn = "0265-0568",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Approaches to identify, clone, and express symbiont bioactive metabolite genes

AU - Hildebrand, Mark

AU - Waggoner, Laura E.

AU - Lim, Grace E.

AU - Sharp, Katherine H.

AU - Ridley, Christian P.

AU - Haygood, Margo G.

PY - 2004/2

Y1 - 2004/2

N2 - This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

AB - This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

UR - http://www.scopus.com/inward/record.url?scp=1342268922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1342268922&partnerID=8YFLogxK

U2 - 10.1039/b302336m

DO - 10.1039/b302336m

M3 - Review article

C2 - 15039839

AN - SCOPUS:1342268922

SN - 0265-0568

VL - 21

SP - 122

EP - 142

JO - Natural Product Reports

JF - Natural Product Reports

IS - 1

ER -

Approaches to identify, clone, and express symbiont bioactive metabolite genes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this