TY - JOUR
T1 - Applications of nanoparticles in biomedical imaging
AU - Han, Xiangjun
AU - Xu, Ke
AU - Taratula, Olena
AU - Farsad, Khashayar
N1 - Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019/1/21
Y1 - 2019/1/21
N2 - An urgent need for early detection and diagnosis of diseases continuously pushes the advancements of imaging modalities and contrast agents. Current challenges remain for fast and detailed imaging of tissue microstructures and lesion characterization that could be achieved via development of nontoxic contrast agents with longer circulation time. Nanoparticle technology offers this possibility. Here, we review nanoparticle-based contrast agents employed in most common biomedical imaging modalities, including fluorescence imaging, MRI, CT, US, PET and SPECT, addressing their structure related features, advantages and limitations. Furthermore, their applications in each imaging modality are also reviewed using commonly studied examples. Future research will investigate multifunctional nanoplatforms to address safety, efficacy and theranostic capabilities. Nanoparticles as imaging contrast agents have promise to greatly benefit clinical practice.
AB - An urgent need for early detection and diagnosis of diseases continuously pushes the advancements of imaging modalities and contrast agents. Current challenges remain for fast and detailed imaging of tissue microstructures and lesion characterization that could be achieved via development of nontoxic contrast agents with longer circulation time. Nanoparticle technology offers this possibility. Here, we review nanoparticle-based contrast agents employed in most common biomedical imaging modalities, including fluorescence imaging, MRI, CT, US, PET and SPECT, addressing their structure related features, advantages and limitations. Furthermore, their applications in each imaging modality are also reviewed using commonly studied examples. Future research will investigate multifunctional nanoplatforms to address safety, efficacy and theranostic capabilities. Nanoparticles as imaging contrast agents have promise to greatly benefit clinical practice.
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U2 - 10.1039/c8nr07769j
DO - 10.1039/c8nr07769j
M3 - Review article
C2 - 30603750
AN - SCOPUS:85060123914
SN - 2040-3364
VL - 11
SP - 799
EP - 819
JO - Nanoscale
JF - Nanoscale
IS - 3
ER -