Applications of nanoparticles in biomedical imaging

Xiangjun Han, Ke Xu, Olena Taratula, Khashayar Farsad

Research output: Contribution to journalReview articlepeer-review

206 Scopus citations


An urgent need for early detection and diagnosis of diseases continuously pushes the advancements of imaging modalities and contrast agents. Current challenges remain for fast and detailed imaging of tissue microstructures and lesion characterization that could be achieved via development of nontoxic contrast agents with longer circulation time. Nanoparticle technology offers this possibility. Here, we review nanoparticle-based contrast agents employed in most common biomedical imaging modalities, including fluorescence imaging, MRI, CT, US, PET and SPECT, addressing their structure related features, advantages and limitations. Furthermore, their applications in each imaging modality are also reviewed using commonly studied examples. Future research will investigate multifunctional nanoplatforms to address safety, efficacy and theranostic capabilities. Nanoparticles as imaging contrast agents have promise to greatly benefit clinical practice.

Original languageEnglish (US)
Pages (from-to)799-819
Number of pages21
Issue number3
StatePublished - Jan 21 2019

ASJC Scopus subject areas

  • Materials Science(all)


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