@article{9454afd0f3b14b13a7ecfbf3682c0d66,
title = "APOE DNA methylation is altered in Lewy body dementia",
abstract = "Introduction: Inheritance of the ε4 allele of apolipoprotein E (APOE) increases a person's risk of developing both Alzheimer's disease (AD) and Lewy body dementia (LBD), yet the underlying mechanisms behind this risk are incompletely understood. The recent identification of reduced APOE DNA methylation in AD postmortem brains prompted this study to investigate APOE methylation in LBD. Methods: Genomic DNA from postmortem brain tissues (frontal lobe and cerebellum) of neuropathological pure (np) controls and npAD, LBD + AD, and npLBD subjects were bisulfite pyrosequenced. DNA methylation levels of two APOE subregions were then compared for these groups. Results: APOE DNA methylation was significantly reduced in npLBD compared with np controls, and methylation levels were lowest in the LBD + AD group. Discussion: Given that npLBD and npAD postmortem brains shared a similar reduction in APOE methylation, it is possible that an aberrant epigenetic change in APOE is linked to risk for both diseases.",
keywords = "Alzheimer's disease (AD), Apolipoprotein E (APOE), Cerebellum, DNA methylation, Dementia with Lewy bodies (DLB), Differential methylation, Differentially methylated region (DMR), Epigenetics, Frontal lobe, Human, Lewy body dementia (LBD), Postmortem brain, Pyrosequencing",
author = "Jessica Tulloch and Lesley Leong and Sunny Chen and Keene, {C. Dirk} and Millard, {Steven P.} and Andrew Shutes-David and Lopez, {Oscar L.} and Julia Kofler and Kaye, {Jeffrey A.} and Randy Woltjer and Nelson, {Peter T.} and Neltner, {Janna H.} and Jicha, {Gregory A.} and Douglas Galasko and Eliezer Masliah and Leverenz, {James B.} and Yu, {Chang En} and Debby Tsuang",
note = "Funding Information: Funding Sources: This work was supported in part by the U.S. Department of Veterans Affairs Office of Research and Development Biomedical Laboratory Research Program and by a grant from the National Institute of Neurological Disorders and Stroke (1R03NS103950). The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. Brain tissues were obtained from donors to the following research centers: University of Washington (UW) Neuropathology Core, which is supported by the Alzheimer's Disease Research Center (AG05136), and the NIA-supported Alzheimer's Disease Centers at the University of Pittsburgh (AG005133), University of California at San Diego (AG005131), University of Kentucky (AG028383), and Oregon Health and Science University (AG008017). Funding Information: Funding Sources: This work was supported in part by the U.S. Department of Veterans Affairs Office of Research and Development Biomedical Laboratory Research Program and by a grant from the National Institute of Neurological Disorders and Stroke (1R03NS103950). The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government. Brain tissues were obtained from donors to the following research centers: University of Washington (UW) Neuropathology Core, which is supported by the Alzheimer's Disease Research Center ( AG05136 ), and the NIA-supported Alzheimer's Disease Centers at the University of Pittsburgh ( AG005133 ), University of California at San Diego ( AG005131 ), University of Kentucky ( AG028383 ), and Oregon Health and Science University ( AG008017 ). Publisher Copyright: {\textcopyright} 2018",
year = "2018",
month = jul,
doi = "10.1016/j.jalz.2018.02.005",
language = "English (US)",
volume = "14",
pages = "889--894",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "7",
}