Antipsychotic drugs and plasma vasopressin in normals and acute schizophrenic patients

Murray A. Raskind, Neelima Courtney, M. Michele Murburg, Frank I. Backus, John A. Bokan, Richard K. Ries, Daniel M. Dorsa, Richard E. Weitzman

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Abstract

Elevated plasma vasopressin concentrations have been documented in antipsychotic drug-treated patients as well as drug-free acutely psychotic patients. To evaluate the effects of antipsychotic drugs on plasma vasopressin, we measured vasopressin response to a single dose of intramuscular chlorpromazine or intravenous haloperidol in normal individuals and to 2 weeks of oral antipsychotics in patients with acute schizophrenia. Neither intramuscular chlorpromazine nor intravenous haloperidol affected plasma vasopressin in normals, except in one subject who developed high plasma vasopressin concentrations coincident with marked hypotension following chlorpromazine. Prior to antipsychotics, two acute schizophrenia patients had elevated plasma vasopressin concentrations, which normalized during antipsychotic drug treatment. We conclude that antipsychotics do not directly stimulate vasopressin release, but may indirectly stimulate vasopressin release by well-described baroreceptor reflex mechanisms if hypotension occurs. Also, acute schizophrenia may be associated with increased plasma vasopressin levels in some patients.

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalBiological Psychiatry
Volume22
Issue number4
DOIs
StatePublished - Apr 1987

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ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Raskind, M. A., Courtney, N., Murburg, M. M., Backus, F. I., Bokan, J. A., Ries, R. K., Dorsa, D. M., & Weitzman, R. E. (1987). Antipsychotic drugs and plasma vasopressin in normals and acute schizophrenic patients. Biological Psychiatry, 22(4), 453-462. https://doi.org/10.1016/0006-3223(87)90167-3