Antimitochondrial antibody-negative primary biliary cirrhosis in an elderly African American man

Haseeb Ilias Basha, Sushma Raju, Rasha Nakhleh, Ghassan Bachuwa

Research output: Contribution to journalReview articlepeer-review

Abstract

Primary biliary cirrhosis (PBC) is a chronic, progressive autoimmune liver disease, which is characterized by nonsuppurative destruction of intrahepatic ducts, resulting in cholestasis, cirrhosis, and end-stage liver disease. Antimitochondrial antibodies (AMAs) are considered to be a highly sensitive and specific serological marker of PBC; however, a subset of patients who have biochemical and histopathological features consistent with PBC do not have detectable AMAs in their serum. This phenomenon is referred to as AMA-negative PBC. This article briefly reviews the literature on AMA-negative PBC and discusses the diagnosis and treatment of this condition in older adults.

Original languageEnglish (US)
Pages (from-to)41-43
Number of pages3
JournalClinical Geriatrics
Volume20
Issue number6
StatePublished - Jun 2012
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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