Antigenic stimulation of active E-rosette-forming lymphocytes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis

Halina Offner, G. Konat, N. J. Legg, N. E. Raun, H. Winterberg, J. Clausen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalClinical Immunology and Immunopathology
Volume16
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

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Systemic Lupus Erythematosus
Multiple Sclerosis
Rheumatoid Arthritis
Lymphocytes
Brain
Myelin Sheath
Antigens
Proteins
Steroids

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Antigenic stimulation of active E-rosette-forming lymphocytes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. / Offner, Halina; Konat, G.; Legg, N. J.; Raun, N. E.; Winterberg, H.; Clausen, J.

In: Clinical Immunology and Immunopathology, Vol. 16, No. 3, 1980, p. 367-373.

Research output: Contribution to journalArticle

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abstract = "Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.",
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AU - Raun, N. E.

AU - Winterberg, H.

AU - Clausen, J.

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N2 - Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.

AB - Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.

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