Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine