Antigenic stimulation of active E-rosette-forming lymphocytes in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis

H. Offner, G. Konat, N. J. Legg, N. E. Raun, H. Winterberg, J. Clausen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Lymphocytes from 73 multiple sclerosis (MS) patients, 58 patients with other neurological diseases (OND), 7 patients with systemic lupus erythematosus (SLE), 34 patients with rheumatoid arthritis (RA), and 10 patients with other diseases were tested for reactivity to brain antigens by the active E-rosette test. Apart from those treated with steroids, all but one of the MS patients, all the SLE patients, and all the RA patients responded to low doses (i.e., 0.1-5 pg total protein) of an acidic extract of MS myelin (MSBP) and of a partially purified protein fraction of MS brain (peak 2). Forty MS patients, one SLE patient, and none of the RA patients responded to an acidic extract of control myelin. Thirty-eight percent of patients with other neurological diseases showed stimulation by both MS and control BP, but none of them responded to MS peak 2 antigen. The results thus indicate a similarity in the response of MS, SLE, and RA patients' lymphocytes to MS brain antigens, but not to normal brain material.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalClinical Immunology and Immunopathology
Volume16
Issue number3
DOIs
StatePublished - Jul 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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