Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung.

Corinne Dot, Joël Guigay, Grazyna Adamus

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

PURPOSE: To present a case of cancer-associated retinopathy (CAR) in a patient with small cell carcinoma of the lung and antiretinal antibodies who experienced visual symptoms before diagnosis of cancer. DESIGN: Case report. METHODS: A 61-year-old man with a sudden loss of vision and photophobia was referred to the ophthalmology service. Antiretinal antibodies were determined by Western blot analysis. RESULTS: The patient was found to have small cell carcinoma of the lung without metastasis and was surgically treated. His visual loss was asymmetrical. The full field ERG was normal, even though his vision in the right eye became progressively worse. The patient was treated with methylprednisolone and showed significant improvement. Before surgery, serum tests showed antiretinal protein 35-kD; 1 week after surgery, antiretinal protein 35-kD and 46-kD (alpha-enolase); and 1 month after surgery, anti-alpha-enolase. CONCLUSIONS: Typical visual symptoms for paraneoplastic retinopathy are not always present. The absence of antirecoverin antibodies does not exclude a diagnosis of CAR.

Original languageEnglish (US)
Pages (from-to)746-747
Number of pages2
JournalAmerican Journal of Ophthalmology
Volume139
Issue number4
StatePublished - Apr 2005
Externally publishedYes

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Ocular Paraneoplastic Syndromes
Phosphopyruvate Hydratase
Small Cell Lung Carcinoma
Antibodies
Photophobia
Methylprednisolone
Ophthalmology
Proteins
Western Blotting
Neoplasm Metastasis
Serum
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung. / Dot, Corinne; Guigay, Joël; Adamus, Grazyna.

In: American Journal of Ophthalmology, Vol. 139, No. 4, 04.2005, p. 746-747.

Research output: Contribution to journalArticle

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