Antesera to the ganglioside GM1 do not have anti-myelin or anti-axon activities in vitro

Dennis N. Bourdette, Bernard Zalc, Nicole Baumann, Frederick J. Seil

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Four antisera to the ganglioside GM1 were tested effects on myelin and axons when applied to mouse spinal cord-dorsal root ganglia explant cultures. None of the antisera to GM1 caused myelination inhibition or demyelination, while an antiserum tto galactocerebroside caused both. Antisera to GM1 did not axonal outgrowth or destroy mature outgrowth zone axons, while an anteserum to a rat brain axolemma-enriched fraction did both. These results suggest that antibodies to GM1 do not have significant anti-myelin or anti-axon activity.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalBrain research
Volume478
Issue number1
DOIs
StatePublished - Jan 23 1989

Keywords

  • Anti-axon antibody
  • Demyelination
  • Ganglioside antibody
  • Myelination inhibition
  • Tissue culture

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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