Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme

Shuang Li, Andrew J. Bieber, Raymond M. Quock

Research output: Contribution to journalArticle

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Abstract

Nitric oxide (NO) has been implicated in the antinociceptive effect of nitrous oxide (N2O) in mice. This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS). The AS-ODN significantly antagonized the antinociceptive effect of N2O in the abdominal constriction test, but a mismatch ODN was without effect. This result implicates the specific involvement of nNOS in N2O-induced antinociception.

Original languageEnglish (US)
Pages (from-to)361-363
Number of pages3
JournalBehavioural Brain Research
Volume152
Issue number2
DOIs
StatePublished - Jul 9 2004

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Keywords

  • Antinociceptive effect
  • Antisense
  • Mice
  • Nitric oxide
  • Nitrous oxide

ASJC Scopus subject areas

  • Behavioral Neuroscience

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