Angucyclinones from an Indonesian Streptomyces sp.

Serge Fotso, Taifo Mahmud, T. Mark Zabriskie, Dwi Andreas Santosa, Sulastri, Philip J. Proteau

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Six new angucyclinone polyketides named panglimycins A-F were isolated together with the three known metabolites (+)-fujianmycin A, (+)-ochromycinone, and emycin C from the bioassay-guided fractionation of the extract of the Indonesian Streptomyces strain ICBB8230. The new compounds are highly oxygenated angucyclinones that appear to be biosynthetically derived from ochromycinone or fujianmycin. Their structures were determined by X-ray crystal analysis, interpretation of 1D- and 2D-NMR spectra, and comparison of the data with those of structurally related known natural products. Despite structural similarities to angucyclinones with antibiotic activities, the panglimycins did not exhibit any growth inhibition when tested against several bacteria and fungi.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalJournal of Natural Products
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Fotso, S., Mahmud, T., Zabriskie, T. M., Santosa, D. A., Sulastri, & Proteau, P. J. (2008). Angucyclinones from an Indonesian Streptomyces sp. Journal of Natural Products, 71(1), 61-65. https://doi.org/10.1021/np0704102