Angucyclinones from an Indonesian Streptomyces sp.

Serge Fotso; Taifo Mahmud; T. Mark Zabriskie; Dwi Andreas Santosa; Sulastri; Philip J. Proteau

doi:10.1021/np0704102

Angucyclinones from an Indonesian Streptomyces sp.

Serge Fotso, Taifo Mahmud, T. Mark Zabriskie, Dwi Andreas Santosa, Sulastri, Philip J. Proteau

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Six new angucyclinone polyketides named panglimycins A-F were isolated together with the three known metabolites (+)-fujianmycin A, (+)-ochromycinone, and emycin C from the bioassay-guided fractionation of the extract of the Indonesian Streptomyces strain ICBB8230. The new compounds are highly oxygenated angucyclinones that appear to be biosynthetically derived from ochromycinone or fujianmycin. Their structures were determined by X-ray crystal analysis, interpretation of 1D- and 2D-NMR spectra, and comparison of the data with those of structurally related known natural products. Despite structural similarities to angucyclinones with antibiotic activities, the panglimycins did not exhibit any growth inhibition when tested against several bacteria and fungi.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Journal of Natural Products
Volume	71
Issue number	1
DOIs	https://doi.org/10.1021/np0704102
State	Published - Jan 2008
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Six new angucyclinone polyketides named panglimycins A-F were isolated together with the three known metabolites (+)-fujianmycin A, (+)-ochromycinone, and emycin C from the bioassay-guided fractionation of the extract of the Indonesian Streptomyces strain ICBB8230. The new compounds are highly oxygenated angucyclinones that appear to be biosynthetically derived from ochromycinone or fujianmycin. Their structures were determined by X-ray crystal analysis, interpretation of 1D- and 2D-NMR spectra, and comparison of the data with those of structurally related known natural products. Despite structural similarities to angucyclinones with antibiotic activities, the panglimycins did not exhibit any growth inhibition when tested against several bacteria and fungi.",

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T1 - Angucyclinones from an Indonesian Streptomyces sp.

AU - Fotso, Serge

AU - Mahmud, Taifo

AU - Zabriskie, T. Mark

AU - Santosa, Dwi Andreas

AU - Sulastri,

AU - Proteau, Philip J.

PY - 2008/1

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Angucyclinones from an Indonesian Streptomyces sp.

Abstract

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