Angiotensin mediated interaction of fetal kidney and placenta in the control of fetal arterial pressure and its role in hydrops fetalis

J. J. Faber, Debra Anderson

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    Fetal cardiovascular control is effected by an interaction of the fetal somatic and placental circulations. Three primary regulatory mechanisms are involved: transplacental transfer of extracellular fluid, driven by a difference in hydrostatic and oncotic pressures; modulation of fetal placental and somatic vascular resistances by means of blood pressure controlled production of angiotensin; and somatic autoregulation of flow. A systems analysis incorporates these and other fetal cardiovascular functions and this analysis was modelled for computer simulation. Given physiologically plausible values for known cardiovascular parameters in the fetal sheep, the model reproduced in detail a variety of experimental protocols with known outcomes; these included the normal fetus, the fetus after bilateral nephrectomy, the nephrectomized fetus infused with angiotensin, the intact fetus infused with NaCl solutions, the fetus with lymphatic obstruction and the severely anaemic fetus. The systems analysis demonstrated that fetal cardiac failure constituted the strongest stimulus for the formation of fetal oedema of any tested pathological intervention.

    Original languageEnglish (US)
    Pages (from-to)313-326
    Number of pages14
    JournalPlacenta
    Volume18
    Issue number4
    DOIs
    StatePublished - 1997

    Fingerprint

    Hydrops Fetalis
    Angiotensins
    Placenta
    Arterial Pressure
    Fetus
    Kidney
    Systems Analysis
    Placental Circulation
    Hydrostatic Pressure
    Extracellular Fluid
    Nephrectomy
    Vascular Resistance
    Computer Simulation
    Sheep
    Homeostasis
    Heart Failure
    Blood Pressure

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    Angiotensin mediated interaction of fetal kidney and placenta in the control of fetal arterial pressure and its role in hydrops fetalis. / Faber, J. J.; Anderson, Debra.

    In: Placenta, Vol. 18, No. 4, 1997, p. 313-326.

    Research output: Contribution to journalArticle

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