Angiotensin II receptor blockade with losartan does not increase baroreflex gain in conscious, pregnant rabbits

L. S. Welch, C. M. Kane, Virginia Brooks

Research output: Contribution to journalArticle

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Abstract

Pregnancy is associated with decreases in the slope or gain of baroreflex relationships between arterial blood pressure (BP) and heart rate (HR) or sympathetic activity. Plasma angiotensin II (AII) levels increase during pregnancy, and in some circumstances AII has been shown to decrease baroreflex gain. Therefore, the hypothesis that the reduced gain of pregnancy is mediated by increased AII was tested by determining if blockade of AII type 1 receptors with losartan (LOS; 5 mg/kg bolus followed by 40 μg/min infusion) increases gain in pregnant (P), but not nonpregnant (NP), conscious rabbits (n=7). Baroreflex curves were generated by changing BP with nitroprusside and phenylephrine and recording changes in HR. Before LOS, P rabbits exhibited reduced BP (68±1 vs. 59±3 mmHg; p

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
Publication statusPublished - Mar 20 1998

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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