Angiomatoid melanoma: A case of metastatic melanoma mimicking a vascular malignancy

Michael J. Adler, Jay Beckstead, Clifton White

Research output: Contribution to journalArticle

22 Scopus citations


We present a case of melanoma metastatic to forehead skin and sacral vertebra, without known primary, which, in the cutaneous metastasis, displayed striking histologic features suggesting vascular differentiation. Histopathologic examination of the lesion revealed a large, deeply extending spindle cell malignancy with numerous, cavernous, erythrocyte-filled spaces throughout and only scant melanin pigmentation, making initial diagnosis challenging. The neoplastic cells demonstrated positive staining with antibodies to S-100 protein, HMB 45, and vimentin. We suggest the term angiomatoid melanoma for this histopathologic variant.

Original languageEnglish (US)
Pages (from-to)606-609
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number6
Publication statusPublished - 1997



  • Angiomatoid metastatic melanoma
  • Malignancy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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