TY - JOUR
T1 - Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT
AU - Pi, Shaohua
AU - Camino, Acner
AU - Zhang, Miao
AU - Cepurna, William
AU - Liu, Gangjun
AU - Huang, David
AU - Morrison, John
AU - Jia, Yali
N1 - Publisher Copyright:
© 2017 Optical Society of America.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiberbased, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.
AB - Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiberbased, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.
KW - (100.2980) image enhancement
KW - (110.4500) optical coherence tomography
KW - (170.2655) functional monitoring and imaging
KW - (170.4470) ophthalmology
UR - http://www.scopus.com/inward/record.url?scp=85031008276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031008276&partnerID=8YFLogxK
U2 - 10.1364/BOE.8.004595
DO - 10.1364/BOE.8.004595
M3 - Article
AN - SCOPUS:85031008276
SN - 2156-7085
VL - 8
SP - 4595
EP - 4608
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 10
M1 - #304064
ER -