Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT

Shaohua Pi, Acner Camino, Miao Zhang, William Cepurna, Gangjun Liu, David Huang, John Morrison, Yali Jia

Research output: Research - peer-reviewArticle

Abstract

Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiberbased, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.

LanguageEnglish (US)
Article number#304064
Pages4595-4608
Number of pages14
JournalBiomedical Optics Express
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2017

Fingerprint

retina
rats
fibers
Retina
Light
chickens
embryos
vessels
tomography
Optical Coherence Tomography
Chickens
Embryonic Structures
nerve fibers
blood vessels
boundary layers
light sources
bandwidth
high resolution
Microvessels
Nerve Fibers

Keywords

  • (100.2980) image enhancement
  • (110.4500) optical coherence tomography
  • (170.2655) functional monitoring and imaging
  • (170.4470) ophthalmology

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT. / Pi, Shaohua; Camino, Acner; Zhang, Miao; Cepurna, William; Liu, Gangjun; Huang, David; Morrison, John; Jia, Yali.

In: Biomedical Optics Express, Vol. 8, No. 10, #304064, 01.10.2017, p. 4595-4608.

Research output: Research - peer-reviewArticle

Pi S, Camino A, Zhang M, Cepurna W, Liu G, Huang D et al. Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT. Biomedical Optics Express. 2017 Oct 1;8(10):4595-4608. #304064. Available from, DOI: 10.1364/BOE.8.004595
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