Androgens and bone growth: It's location, location, location

Kristine M. Wiren

doi:10.1016/j.coph.2005.06.003

Androgens and bone growth: It's location, location, location

Kristine M. Wiren

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.

Original language	English (US)
Pages (from-to)	626-632
Number of pages	7
Journal	Current Opinion in Pharmacology
Volume	5
Issue number	6 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.coph.2005.06.003
State	Published - Dec 2005
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.coph.2005.06.003

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title = "Androgens and bone growth: It's location, location, location",

abstract = "Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.",

author = "Wiren, {Kristine M.}",

note = "Funding Information: I would like to thank Karl Jepsen, Shun-Ichi Harada, Michael Gentile and Xiao-Wei Zhang for their contributions to this work. This work is funded by Veterans Affairs Medical Research Service Merit Review program and the Department of Defense, United States Army Research Acquisition Activity Award No. W81XWH-05-1-0086.",

year = "2005",

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doi = "10.1016/j.coph.2005.06.003",

language = "English (US)",

volume = "5",

pages = "626--632",

journal = "Current Opinion in Pharmacology",

issn = "1471-4892",

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TY - JOUR

T1 - Androgens and bone growth

T2 - It's location, location, location

AU - Wiren, Kristine M.

N1 - Funding Information: I would like to thank Karl Jepsen, Shun-Ichi Harada, Michael Gentile and Xiao-Wei Zhang for their contributions to this work. This work is funded by Veterans Affairs Medical Research Service Merit Review program and the Department of Defense, United States Army Research Acquisition Activity Award No. W81XWH-05-1-0086.

PY - 2005/12

Y1 - 2005/12

N2 - Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.

AB - Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.

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U2 - 10.1016/j.coph.2005.06.003

DO - 10.1016/j.coph.2005.06.003

M3 - Review article

C2 - 16185926

AN - SCOPUS:27744521675

SN - 1471-4892

VL - 5

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JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

IS - 6 SPEC. ISS.

ER -

Androgens and bone growth: It's location, location, location

Abstract

ASJC Scopus subject areas

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