Androgens and bone growth: It's location, location, location

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.

Original languageEnglish (US)
Pages (from-to)626-632
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume5
Issue number6 SPEC. ISS.
DOIs
StatePublished - Dec 2005

Fingerprint

Bone Development
Androgens
Bone and Bones
Androgen Receptors
Osteoclasts
Osteoblasts
Transcriptional Activation
Estrogens

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Androgens and bone growth : It's location, location, location. / Wiren, Kristine.

In: Current Opinion in Pharmacology, Vol. 5, No. 6 SPEC. ISS., 12.2005, p. 626-632.

Research output: Contribution to journalArticle

@article{165b71d390064dc583fb146e28b4d808,
title = "Androgens and bone growth: It's location, location, location",
abstract = "Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.",
author = "Kristine Wiren",
year = "2005",
month = "12",
doi = "10.1016/j.coph.2005.06.003",
language = "English (US)",
volume = "5",
pages = "626--632",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",
number = "6 SPEC. ISS.",

}

TY - JOUR

T1 - Androgens and bone growth

T2 - It's location, location, location

AU - Wiren, Kristine

PY - 2005/12

Y1 - 2005/12

N2 - Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.

AB - Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.

UR - http://www.scopus.com/inward/record.url?scp=27744521675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27744521675&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2005.06.003

DO - 10.1016/j.coph.2005.06.003

M3 - Article

C2 - 16185926

AN - SCOPUS:27744521675

VL - 5

SP - 626

EP - 632

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

IS - 6 SPEC. ISS.

ER -