Androgen receptor polymorphisms and the incidence of prostate cancer

Chu Chen, Najib Lamharzi, Noel S. Weiss, Ruth Etzioni, Douglas A. Dightman, Matt Barnett, Dante DiTommaso, Gary Goodman

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61 Scopus citations

Abstract

The human androgen receptor gene contains polymorphic CAG and GGC repeats in exon 1. We investigated whether the number of CAG and/or GGC repeats is related to prostate cancer risk in a case-control study nested within the β Carotene and Retinol Efficacy Trial. Among 300 cases and 300 controls, we did not observe any increase in risk associated with fewer CAG or GGC repeats. We observed a nonsignificant decrease in risk associated with each unit of decrease in CAG length [odds ratio (OR), 0.98; 95% confidence interval (CI), 0.93-1.03). Men with CAG <22 had a relative risk of prostate cancer of 0.89 (95% CI, 0.65-1.23) compared with men with CAG ≥22. There was no appreciable difference in the mean number of GGC repeats between cases and controls; the estimated change in the risk of prostate cancer associated with one fewer GGC repeat was 0.97 (95% CI, 0.88-1.06). The risk in men at or below the mean number of GGC repeats (17) was 0.80 (95% CI, 0.57-1.12). In contrast to prior reports, men with both short CAG (<22) and short GGC (≤17) repeats were not at increased risk of prostate cancer (OR, 0.56; 95% CI, 0.32-0.98), compared with men with ≥22 CAG repeats and >17 GGC repeats. Our results do not support the hypothesis that a small number of CAG or GGC repeats in the androgen receptor gene increases a man's risk of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1033-1040
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume11
Issue number10 I
StatePublished - Oct 1 2002

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ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Chen, C., Lamharzi, N., Weiss, N. S., Etzioni, R., Dightman, D. A., Barnett, M., DiTommaso, D., & Goodman, G. (2002). Androgen receptor polymorphisms and the incidence of prostate cancer. Cancer Epidemiology Biomarkers and Prevention, 11(10 I), 1033-1040.