Anatomical substrates for baroreflex sympathoinhibition in the rat

Sue Aicher, Teresa A. Milner, Virginia M. Pickel, Donald J. Reis

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The fundamental neuronal substrates of the arterial baroreceptor reflex have been elucidated by combining anatomical, neurophysiological, and pharmacological approaches. A serial pathway between neurons located in the nuclei of the solitary tract (NTS), the caudal ventrolateral medulla (CVL), and the rostral ventrolateral medulla (RVL) plays a critical role in inhibition of sympathetic outflow following stimulation of baroreceptor afferents. In this paper, we summarize our studies using tract-tracing and electron microscopic immunocytochemistry to define the potential functional sites for synaptic transmission within this circuitry. The results are discussed as they relate to the literature showing: (1) baroreceptor afferents excite second-order neurons in NTS through the release of glutamate; (2) these NTS neurons in turn send excitatory projections to neurons in the CVL; (3) GABAergic CVL neurons directly inhibit RVL sympathoexcitatory neurons; and (4) activation of this NTS→CVL→RVL pathway leads to disfacilitation of sympathetic preganglionic neurons by promoting withdrawal of their tonic excitatory drive, which largely arises from neurons in the RVL. Baroreceptor control may also be regulated over direct reticulospinal pathways exemplified by a newly recognized sympathoinhibitory region of the medulla, the gigantocellular depressor area. This important autonomic reflex may also be influenced by parallel, multiple, and redundant networks. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalBrain Research Bulletin
Volume51
Issue number2
DOIs
StatePublished - Jan 15 2000
Externally publishedYes

Fingerprint

Baroreflex
Neurons
Pressoreceptors
Solitary Nucleus
Synaptic Transmission
Reflex
Glutamic Acid
Immunohistochemistry
Pharmacology
Electrons

Keywords

  • Blood pressure
  • Cardiovascular
  • Caudal ventrolateral medulla
  • Nucleus tractus solitarius
  • Rostral ventrolateral medulla
  • Ultrastructure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anatomical substrates for baroreflex sympathoinhibition in the rat. / Aicher, Sue; Milner, Teresa A.; Pickel, Virginia M.; Reis, Donald J.

In: Brain Research Bulletin, Vol. 51, No. 2, 15.01.2000, p. 107-110.

Research output: Contribution to journalArticle

Aicher, Sue ; Milner, Teresa A. ; Pickel, Virginia M. ; Reis, Donald J. / Anatomical substrates for baroreflex sympathoinhibition in the rat. In: Brain Research Bulletin. 2000 ; Vol. 51, No. 2. pp. 107-110.
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