Anaphylactic shock with ventricular fibrillation induced by chlorhexidine

I. Harukuni, Y. Ishizawa, T. Nishikawa, R. Takeshima, S. Dohi, H. Naito

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We experienced a case in which a 66 year-old male patient developed anaphylactic shock followed by ventricular fibrillation, possibly due to intravenous aspiration of chlorhexidine used for topical application when right internal jugular vein was punctured. He was successfully resuscitated without any sequelae. Although lymphocyte transformation test failed to identify the specific allergen, IgE antibodies against chlorhexidine in the patient's serum were detected by radioallergosorbent technique. Chlorhexidine is an extensively used antiseptic, but there have been many reports regarding severe adverse reactions associated with its use. Chlorhexidine does not seem to be a safe antiseptic.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
JournalJapanese Journal of Anesthesiology
Issue number3
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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