Analysis of bending behavior of native and engineered auricular and costal cartilage

Rani Roy, Sean Kohles, Victor Zaporojan, Giuseppe M. Peretti, Mark A. Randolph, Jianwei Xu, Lawrence J. Bonassar

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A large-deflection elasticity model was used to describe the mechanical behavior of cartilaginous tissues during three-point bending tests. Force-deflection curves were measured for 20-mm long × 4-mm wide × ≈1-mm thick strips of porcine auricular and costal cartilage. Using a least-squares method with elastic modulus in bending as the only adjustable parameter, data were fit to a model based on the von Karman theory for large deflection of plates. This model described the data well, with an average RMS error of 14.8% and an average R2 value of 0.98. Using this method, the bending modulus of auricular cartilage (4.6 MPa) was found to be statistically lower (p <0.05) than that of costal cartilage (7.1 MPa). Material features of the cartilage samples influenced the mechanical behavior, including the orientation of the perichondrium in auricular cartilage. These methods also were used to determine the elastic moduli of engineered cartilage samples produced by seeding chondrocytes into fibrin glue. The modulus of tissue-engineered constructs increased statistically with time (p <0.05), but still were statistically lower than the moduli of the native tissue samples (p > 0.05), reaching only about a third of the values of native samples.

Original languageEnglish (US)
Pages (from-to)597-602
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume68
Issue number4
StatePublished - Mar 15 2004
Externally publishedYes

Fingerprint

Cartilage
Bending tests
Elasticity
Elastic moduli
Tissue

Keywords

  • Auricular cartilage
  • Biomechanics
  • Large-deflection bending
  • Soft-tissue deformation
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Roy, R., Kohles, S., Zaporojan, V., Peretti, G. M., Randolph, M. A., Xu, J., & Bonassar, L. J. (2004). Analysis of bending behavior of native and engineered auricular and costal cartilage. Journal of Biomedical Materials Research - Part A, 68(4), 597-602.

Analysis of bending behavior of native and engineered auricular and costal cartilage. / Roy, Rani; Kohles, Sean; Zaporojan, Victor; Peretti, Giuseppe M.; Randolph, Mark A.; Xu, Jianwei; Bonassar, Lawrence J.

In: Journal of Biomedical Materials Research - Part A, Vol. 68, No. 4, 15.03.2004, p. 597-602.

Research output: Contribution to journalArticle

Roy, R, Kohles, S, Zaporojan, V, Peretti, GM, Randolph, MA, Xu, J & Bonassar, LJ 2004, 'Analysis of bending behavior of native and engineered auricular and costal cartilage', Journal of Biomedical Materials Research - Part A, vol. 68, no. 4, pp. 597-602.
Roy R, Kohles S, Zaporojan V, Peretti GM, Randolph MA, Xu J et al. Analysis of bending behavior of native and engineered auricular and costal cartilage. Journal of Biomedical Materials Research - Part A. 2004 Mar 15;68(4):597-602.
Roy, Rani ; Kohles, Sean ; Zaporojan, Victor ; Peretti, Giuseppe M. ; Randolph, Mark A. ; Xu, Jianwei ; Bonassar, Lawrence J. / Analysis of bending behavior of native and engineered auricular and costal cartilage. In: Journal of Biomedical Materials Research - Part A. 2004 ; Vol. 68, No. 4. pp. 597-602.
@article{07e8cae029e24a10822c798ab0f7580a,
title = "Analysis of bending behavior of native and engineered auricular and costal cartilage",
abstract = "A large-deflection elasticity model was used to describe the mechanical behavior of cartilaginous tissues during three-point bending tests. Force-deflection curves were measured for 20-mm long × 4-mm wide × ≈1-mm thick strips of porcine auricular and costal cartilage. Using a least-squares method with elastic modulus in bending as the only adjustable parameter, data were fit to a model based on the von Karman theory for large deflection of plates. This model described the data well, with an average RMS error of 14.8{\%} and an average R2 value of 0.98. Using this method, the bending modulus of auricular cartilage (4.6 MPa) was found to be statistically lower (p <0.05) than that of costal cartilage (7.1 MPa). Material features of the cartilage samples influenced the mechanical behavior, including the orientation of the perichondrium in auricular cartilage. These methods also were used to determine the elastic moduli of engineered cartilage samples produced by seeding chondrocytes into fibrin glue. The modulus of tissue-engineered constructs increased statistically with time (p <0.05), but still were statistically lower than the moduli of the native tissue samples (p > 0.05), reaching only about a third of the values of native samples.",
keywords = "Auricular cartilage, Biomechanics, Large-deflection bending, Soft-tissue deformation, Tissue engineering",
author = "Rani Roy and Sean Kohles and Victor Zaporojan and Peretti, {Giuseppe M.} and Randolph, {Mark A.} and Jianwei Xu and Bonassar, {Lawrence J.}",
year = "2004",
month = "3",
day = "15",
language = "English (US)",
volume = "68",
pages = "597--602",
journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",
issn = "1552-4973",
publisher = "Heterocorporation",
number = "4",

}

TY - JOUR

T1 - Analysis of bending behavior of native and engineered auricular and costal cartilage

AU - Roy, Rani

AU - Kohles, Sean

AU - Zaporojan, Victor

AU - Peretti, Giuseppe M.

AU - Randolph, Mark A.

AU - Xu, Jianwei

AU - Bonassar, Lawrence J.

PY - 2004/3/15

Y1 - 2004/3/15

N2 - A large-deflection elasticity model was used to describe the mechanical behavior of cartilaginous tissues during three-point bending tests. Force-deflection curves were measured for 20-mm long × 4-mm wide × ≈1-mm thick strips of porcine auricular and costal cartilage. Using a least-squares method with elastic modulus in bending as the only adjustable parameter, data were fit to a model based on the von Karman theory for large deflection of plates. This model described the data well, with an average RMS error of 14.8% and an average R2 value of 0.98. Using this method, the bending modulus of auricular cartilage (4.6 MPa) was found to be statistically lower (p <0.05) than that of costal cartilage (7.1 MPa). Material features of the cartilage samples influenced the mechanical behavior, including the orientation of the perichondrium in auricular cartilage. These methods also were used to determine the elastic moduli of engineered cartilage samples produced by seeding chondrocytes into fibrin glue. The modulus of tissue-engineered constructs increased statistically with time (p <0.05), but still were statistically lower than the moduli of the native tissue samples (p > 0.05), reaching only about a third of the values of native samples.

AB - A large-deflection elasticity model was used to describe the mechanical behavior of cartilaginous tissues during three-point bending tests. Force-deflection curves were measured for 20-mm long × 4-mm wide × ≈1-mm thick strips of porcine auricular and costal cartilage. Using a least-squares method with elastic modulus in bending as the only adjustable parameter, data were fit to a model based on the von Karman theory for large deflection of plates. This model described the data well, with an average RMS error of 14.8% and an average R2 value of 0.98. Using this method, the bending modulus of auricular cartilage (4.6 MPa) was found to be statistically lower (p <0.05) than that of costal cartilage (7.1 MPa). Material features of the cartilage samples influenced the mechanical behavior, including the orientation of the perichondrium in auricular cartilage. These methods also were used to determine the elastic moduli of engineered cartilage samples produced by seeding chondrocytes into fibrin glue. The modulus of tissue-engineered constructs increased statistically with time (p <0.05), but still were statistically lower than the moduli of the native tissue samples (p > 0.05), reaching only about a third of the values of native samples.

KW - Auricular cartilage

KW - Biomechanics

KW - Large-deflection bending

KW - Soft-tissue deformation

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=1342302203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1342302203&partnerID=8YFLogxK

M3 - Article

C2 - 14986315

AN - SCOPUS:1342302203

VL - 68

SP - 597

EP - 602

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

SN - 1552-4973

IS - 4

ER -