Analogs of 5-methylthioribose, a novel class of antiprotozoal agents

Michael Riscoe, A. J. Ferro, J. H. Fitchen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Since drug resistance and toxicity limit the use of available antiprotozoal agents, it is important that new drugs be developed as soon as possible. In this study, the method by which several protozoa degrade 5'-methylthioadenosine (MTA) was shown to differ from MTA catabolism in human cells. To exploit this metabolic difference, two analogs of methylthioribose (MTR), an MTA catabolite, were synthesized and found to be cytocidal to Plasmodium falciparum, Giardia lamblia, and Ochromonas malhamensis in vitro. In contrast, these analogs had no effect on cultured mammalian cells. Analogs of MTR represent a potential new class of antiprotozoal drugs.

Original languageEnglish (US)
Pages (from-to)1904-1906
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume32
Issue number12
StatePublished - 1988
Externally publishedYes

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Antiprotozoal Agents
Ochromonas
Giardia lamblia
Plasmodium falciparum
Drug-Related Side Effects and Adverse Reactions
Drug Resistance
Pharmaceutical Preparations
Cultured Cells
5-methylthioribose

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Analogs of 5-methylthioribose, a novel class of antiprotozoal agents. / Riscoe, Michael; Ferro, A. J.; Fitchen, J. H.

In: Antimicrobial Agents and Chemotherapy, Vol. 32, No. 12, 1988, p. 1904-1906.

Research output: Contribution to journalArticle

Riscoe, Michael ; Ferro, A. J. ; Fitchen, J. H. / Analogs of 5-methylthioribose, a novel class of antiprotozoal agents. In: Antimicrobial Agents and Chemotherapy. 1988 ; Vol. 32, No. 12. pp. 1904-1906.
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