An oxidatively releasable caging group that senses lipid peroxidation

Kari A. Trumbull; Bruce P. Branchaud

doi:10.1016/j.bmcl.2005.08.079

An oxidatively releasable caging group that senses lipid peroxidation

Kari A. Trumbull, Bruce P. Branchaud

Knight Cancer Institute

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.

Original language	English (US)
Pages (from-to)	5544-5547
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2005.08.079
State	Published - Dec 15 2005

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Keywords

Caging group
Lipid peroxidation
Radical reaction mechanism
Reactive oxygen species

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Trumbull, K. A., & Branchaud, B. P. (2005). An oxidatively releasable caging group that senses lipid peroxidation. Bioorganic and Medicinal Chemistry Letters, 15(24), 5544-5547. https://doi.org/10.1016/j.bmcl.2005.08.079

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Access to Document

10.1016/j.bmcl.2005.08.079