An oxidatively releasable caging group that senses lipid peroxidation

Kari A. Trumbull; Bruce P. Branchaud

doi:10.1016/j.bmcl.2005.08.079

An oxidatively releasable caging group that senses lipid peroxidation

Kari A. Trumbull, Bruce P. Branchaud

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.

Original language	English (US)
Pages (from-to)	5544-5547
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2005.08.079
State	Published - Dec 15 2005
Externally published	Yes

Keywords

Caging group
Lipid peroxidation
Radical reaction mechanism
Reactive oxygen species

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.08.079

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abstract = "A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.",

keywords = "Caging group, Lipid peroxidation, Radical reaction mechanism, Reactive oxygen species",

author = "Trumbull, {Kari A.} and Branchaud, {Bruce P.}",

note = "Funding Information: We thank the American Heart Association (0450118Z) and the National Science Foundation (DGE-0231997) for financial support. ",

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AU - Trumbull, Kari A.

AU - Branchaud, Bruce P.

N1 - Funding Information: We thank the American Heart Association (0450118Z) and the National Science Foundation (DGE-0231997) for financial support.

PY - 2005/12/15

Y1 - 2005/12/15

N2 - A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.

AB - A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.

KW - Caging group

KW - Lipid peroxidation

KW - Radical reaction mechanism

KW - Reactive oxygen species

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JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 24

ER -

An oxidatively releasable caging group that senses lipid peroxidation

Abstract

Keywords

ASJC Scopus subject areas

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