An oxidatively releasable caging group that senses lipid peroxidation

Kari A. Trumbull, Bruce P. Branchaud

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.

Original languageEnglish (US)
Pages (from-to)5544-5547
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number24
DOIs
StatePublished - Dec 15 2005

Keywords

  • Caging group
  • Lipid peroxidation
  • Radical reaction mechanism
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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