Abstract
A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5544-5547 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 15 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 15 2005 |
| Externally published | Yes |
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Keywords
- Caging group
- Lipid peroxidation
- Radical reaction mechanism
- Reactive oxygen species
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
An oxidatively releasable caging group that senses lipid peroxidation. / Trumbull, Kari A.; Branchaud, Bruce.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 24, 15.12.2005, p. 5544-5547.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An oxidatively releasable caging group that senses lipid peroxidation
AU - Trumbull, Kari A.
AU - Branchaud, Bruce
PY - 2005/12/15
Y1 - 2005/12/15
N2 - A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.
AB - A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.
KW - Caging group
KW - Lipid peroxidation
KW - Radical reaction mechanism
KW - Reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=27644594224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27644594224&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.08.079
DO - 10.1016/j.bmcl.2005.08.079
M3 - Article
C2 - 16202588
AN - SCOPUS:27644594224
VL - 15
SP - 5544
EP - 5547
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 24
ER -