Abstract
A new radical-sensitive caging technique releases a caged molecule under lipid peroxidation conditions. In a competitive oxidation study with a model lipid, methyl linoleate, the oxidatively releasable xanthenyl caging groups is found to be 1.93 ± 0.55 times more reactive than the lipid model compound.
Original language | English (US) |
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Pages (from-to) | 5544-5547 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 15 |
Issue number | 24 |
DOIs | |
State | Published - Dec 15 2005 |
Externally published | Yes |
Keywords
- Caging group
- Lipid peroxidation
- Radical reaction mechanism
- Reactive oxygen species
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry