An ODE model for the HER2/3-AKT signaling pathway in cancers that overexpress HER2

Solomon Itani, Joe Gray, Claire J. Tomlin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Targeted drug therapies have proven very useful as cancer treatments, but some still demonstrate very little antitumor activity in certain cancers. A class of tyrosine kinase inhibitors (TKIs) that are unexpectedly inefficient in some cancers are those that target the human epidermal growth factor receptor (HER) family. This paper proposes a mathematical model of the HER signaling pathway for the study and treatment of cancers that overexpress. The goals of this paper are threefold. The first is to introduce an ODE model that agrees with the existing data over large time intervals, and the second is to use this model to understand the effects of applying certain drugs to such cancers. We finally use this model to determine a "steering-based" treatment scheme for cancers that overexpress HER2.

Original languageEnglish (US)
Title of host publicationProceedings of the 2010 American Control Conference, ACC 2010
Pages1235-1241
Number of pages7
StatePublished - Oct 15 2010
Event2010 American Control Conference, ACC 2010 - Baltimore, MD, United States
Duration: Jun 30 2010Jul 2 2010

Publication series

NameProceedings of the 2010 American Control Conference, ACC 2010

Other

Other2010 American Control Conference, ACC 2010
CountryUnited States
CityBaltimore, MD
Period6/30/107/2/10

ASJC Scopus subject areas

  • Control and Systems Engineering

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    Itani, S., Gray, J., & Tomlin, C. J. (2010). An ODE model for the HER2/3-AKT signaling pathway in cancers that overexpress HER2. In Proceedings of the 2010 American Control Conference, ACC 2010 (pp. 1235-1241). [5531034] (Proceedings of the 2010 American Control Conference, ACC 2010).