An IRKO in the Podo: Impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy

Susan Gurley, Thomas M. Coffman

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Abstract

Despite its high prevalence, the mechanisms causing diabetic kidney disease remain poorly understood. In this issue of Cell Metabolism, Welsh et al. (2010) show that elimination of insulin receptors from the glomerular podocyte, a cell that is central to the pathogenesis of proteinuric renal diseases, recapitulates many features of human diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)311-312
Number of pages2
JournalCell Metabolism
Volume12
Issue number4
DOIs
StatePublished - Oct 6 2010
Externally publishedYes

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Podocytes
Diabetic Nephropathies
Insulin
Insulin Receptor
Kidney

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

An IRKO in the Podo : Impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy. / Gurley, Susan; Coffman, Thomas M.

In: Cell Metabolism, Vol. 12, No. 4, 06.10.2010, p. 311-312.

Research output: Contribution to journalComment/debate

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