An IRKO in the Podo: Impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy

Susan B. Gurley, Thomas M. Coffman

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

Despite its high prevalence, the mechanisms causing diabetic kidney disease remain poorly understood. In this issue of Cell Metabolism, Welsh et al. (2010) show that elimination of insulin receptors from the glomerular podocyte, a cell that is central to the pathogenesis of proteinuric renal diseases, recapitulates many features of human diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)311-312
Number of pages2
JournalCell Metabolism
Volume12
Issue number4
DOIs
StatePublished - Oct 6 2010

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'An IRKO in the Podo: Impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy'. Together they form a unique fingerprint.

  • Cite this