An in vivo investigation of X-ray sensitivity in fibroblasts from patients with retinoblastoma

R. Weichselbaum, D. M. Albert, J. R. Cassady, J. B. Little

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In vitro x-ray survival experiments were performed in fibroblast strains derived from nine patients with sporadic unilateral retinoblastoma, 26 patients with hereditary retinoblastoma, and six normal controls. The x-ray sensitivity of the strains derived from the sporadic retinoblastoma patients and normal controls did not significantly differ from one another. The fibroblast strains derived from patients with hereditary retinoblastoma were significantly more radiosensitive to killng by x-rays as measured by clonogenic survival than either the sporadic strains or the strains derived from normal controls. We hypothesize that the increased in vitro radiosensitivity observed in some hereditary retinoblastoma strains is a reflection of an as yet uncharacterized defect in DNA or DNA replication postirradiation.

Original languageEnglish (US)
Pages (from-to)958-961
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume24
Issue number7
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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