An evaluation of the role of ethanol clearance rate in the differential response of long-sleep and short-sleep mice to ethanol

Tamara J. Phillips, David M. Gilliam, Bruce C. Dudek

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Ethanol (ETOH) clearance rates were determined in Long-Sleep (LS) and Short-Sleep (SS) mice, which were selectively bred for differential soporific response to ETOH. Determination of blood ethanol levels at 45 min intervals following administration of 3.8 g/kg IP indicated that SS mice clear ETOH at a faster rate. Repeatedly sampled mice of each line cleared ETOH more slowly than those where samples were taken only once. A second experiment utilized pairs of LS and SS mice matched on body weight. These were treated with one of several doses of ETOH, and duration of loss of the righting reflex measured for one member of the pair. Blood ETOH levels were determined in samples taken from both members of the pair when the tested member regained the righting reflex. LS mice had small but consistently higher blood ETOH levels in these pairs. The magnitude of the differences between the LS and SS mice in these experiments indicate that clearance rate differences can account for only a small portion of the differences in behavioral responses of these mice to ETOH.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalAlcohol
Volume1
Issue number5
DOIs
StatePublished - Jan 1 1984

Keywords

  • Alcohol
  • Ethanol clearance
  • LS and SS Mice
  • Pharmacogenetics

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'An evaluation of the role of ethanol clearance rate in the differential response of long-sleep and short-sleep mice to ethanol'. Together they form a unique fingerprint.

  • Cite this