An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night

Frank A J L Scheer, Thomas J. Shea, Michael F. Hilton, Steven Shea

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Sleep inertia is the impaired cognitive performance immediately upon awakening, which decays over tens of minutes. This phenomenon has relevance to people who need to make important decisions soon after awakening, such as on-call emergency workers. Such awakenings can occur at varied times of day or night, so the objective of the study was to determine whether or not the magnitude of sleep inertia varies according to the phase of the endogenous circadian cycle. Twelve adults (mean, 24 years; 7 men) with no medical disorders other than mild asthma were studied. Following 2 baseline days and nights, subjects underwent a forced desynchrony protocol composed of seven 28-h sleep/wake cycles, while maintaining a sleep/wakefulness ratio of 1:2 throughout. Subjects were awakened by a standardized auditory stimulus 3 times each sleep period for sleep inertia assessments. The magnitude of sleep inertia was quantified as the change in cognitive performance (number of correct additions in a 2-min serial addition test) across the first 20 min of wakefulness. Circadian phase was estimated from core body temperature (fitted temperature minimum assigned 0°). Data were segregated according to: (1) circadian phase (60° bins); (2) sleep stage; and (3) 3rd of the night after which awakenings occurred (i.e., tertiary 1, 2, or 3). To control for any effect of sleep stage, the circadian rhythm of sleep inertia was initially assessed following awakenings from Stage 2 (62% of awakening occurred from this stage; n = 110). This revealed a significant circadian rhythm in the sleep inertia of cognitive performance (p = 0.007), which was 3.6 times larger during the biological night (circadian bin 300°, ∼2300-0300 h in these subjects) than during the biological day (bin 180°, ∼1500-1900 h). The circadian rhythm in sleep inertia was still present when awakenings from all sleep stages were included (p = 0.004), and this rhythm could not be explained by changes in underlying sleep drive prior to awakening (changes in sleep efficiency across circadian phase or across the tertiaries), or by the proportion of the varied sleep stages prior to awakenings. This robust endogenous circadian rhythm in sleep inertia may have important implications for people who need to be alert soon after awakening.

Original languageEnglish (US)
Pages (from-to)353-361
Number of pages9
JournalJournal of Biological Rhythms
Volume23
Issue number4
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Circadian Rhythm
sleep
circadian rhythm
Sleep
Sleep Stages
Wakefulness
cognition
Cognitive Dysfunction
Body Temperature
asthma
Emergencies
Asthma
body temperature

Keywords

  • Circadian rhythm
  • Cognitive performance
  • Grogginess
  • Jet lag
  • Shift work
  • Sleep
  • Sleep inertia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Physiology
  • Physiology (medical)

Cite this

An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. / Scheer, Frank A J L; Shea, Thomas J.; Hilton, Michael F.; Shea, Steven.

In: Journal of Biological Rhythms, Vol. 23, No. 4, 08.2008, p. 353-361.

Research output: Contribution to journalArticle

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