An automated statistical technique for counting distinct multiple sclerosis lesions

J. D. Dworkin, K. A. Linn, I. Oguz, G. M. Fleishman, R. Bakshi, G. Nair, P. A. Calabresi, R. G. Henry, J. Oh, N. Papinutto, D. Pelletier, William Rooney, W. Stern, N. L. Sicotte, D. S. Reich, R. T. Shinohara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Lesion load is a common biomarker in multiple sclerosis, yet it has historically shown modest association with clinical outcome. Lesion count, which encapsulates the natural history of lesion formation and is thought to provide complementary information, is difficult to assess in patients with confluent (ie, spatially overlapping) lesions. We introduce a statistical technique for cross-sectionally counting pathologically distinct lesions. MATERIALS AND METHODS: MR imaging was used to assess the probability of a lesion at each location. The texture of this map was quantified using a novel technique, and clusters resembling the center of a lesion were counted. Validity compared with a criterion standard count was demonstrated in 60 subjects observed longitudinally, and reliability was determined using 14 scansofa clinically stable subject acquired at 7 sites. RESULTS: The proposed count and the criterion standard count were highly correlated (r = 0.97, P <.001) and not significantly different (t59 = -.83, P =.41), and the variability of the proposed count across repeat scans was equivalent to that of lesion load. After accounting for lesion load and age, lesion count was negatively associated (t58 = - 2.73, P >.01) with the Expanded Disability Status Scale. Average lesion size had a higher association with the Expanded Disability Status Scale (r = 0.35, P >.01) than lesion load (r = 0.10, P =.44) or lesion count (r = -.12, P =.36) alone. CONCLUSIONS: This study introduces a novel technique for counting pathologically distinct lesions using cross-sectional data and demonstrates its ability to recover obscured longitudinal information. The proposed count allows more accurate estimation of lesion size, which correlated more closely with disability scores than either lesion load or lesion count alone.

Original languageEnglish (US)
Pages (from-to)626-633
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume39
Issue number4
DOIs
StatePublished - Apr 1 2018

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Multiple Sclerosis
Natural History
Biomarkers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Dworkin, J. D., Linn, K. A., Oguz, I., Fleishman, G. M., Bakshi, R., Nair, G., ... Shinohara, R. T. (2018). An automated statistical technique for counting distinct multiple sclerosis lesions. American Journal of Neuroradiology, 39(4), 626-633. https://doi.org/10.3174/ajnr.A5556

An automated statistical technique for counting distinct multiple sclerosis lesions. / Dworkin, J. D.; Linn, K. A.; Oguz, I.; Fleishman, G. M.; Bakshi, R.; Nair, G.; Calabresi, P. A.; Henry, R. G.; Oh, J.; Papinutto, N.; Pelletier, D.; Rooney, William; Stern, W.; Sicotte, N. L.; Reich, D. S.; Shinohara, R. T.

In: American Journal of Neuroradiology, Vol. 39, No. 4, 01.04.2018, p. 626-633.

Research output: Contribution to journalArticle

Dworkin, JD, Linn, KA, Oguz, I, Fleishman, GM, Bakshi, R, Nair, G, Calabresi, PA, Henry, RG, Oh, J, Papinutto, N, Pelletier, D, Rooney, W, Stern, W, Sicotte, NL, Reich, DS & Shinohara, RT 2018, 'An automated statistical technique for counting distinct multiple sclerosis lesions', American Journal of Neuroradiology, vol. 39, no. 4, pp. 626-633. https://doi.org/10.3174/ajnr.A5556
Dworkin, J. D. ; Linn, K. A. ; Oguz, I. ; Fleishman, G. M. ; Bakshi, R. ; Nair, G. ; Calabresi, P. A. ; Henry, R. G. ; Oh, J. ; Papinutto, N. ; Pelletier, D. ; Rooney, William ; Stern, W. ; Sicotte, N. L. ; Reich, D. S. ; Shinohara, R. T. / An automated statistical technique for counting distinct multiple sclerosis lesions. In: American Journal of Neuroradiology. 2018 ; Vol. 39, No. 4. pp. 626-633.
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AU - Dworkin, J. D.

AU - Linn, K. A.

AU - Oguz, I.

AU - Fleishman, G. M.

AU - Bakshi, R.

AU - Nair, G.

AU - Calabresi, P. A.

AU - Henry, R. G.

AU - Oh, J.

AU - Papinutto, N.

AU - Pelletier, D.

AU - Rooney, William

AU - Stern, W.

AU - Sicotte, N. L.

AU - Reich, D. S.

AU - Shinohara, R. T.

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N2 - BACKGROUND AND PURPOSE: Lesion load is a common biomarker in multiple sclerosis, yet it has historically shown modest association with clinical outcome. Lesion count, which encapsulates the natural history of lesion formation and is thought to provide complementary information, is difficult to assess in patients with confluent (ie, spatially overlapping) lesions. We introduce a statistical technique for cross-sectionally counting pathologically distinct lesions. MATERIALS AND METHODS: MR imaging was used to assess the probability of a lesion at each location. The texture of this map was quantified using a novel technique, and clusters resembling the center of a lesion were counted. Validity compared with a criterion standard count was demonstrated in 60 subjects observed longitudinally, and reliability was determined using 14 scansofa clinically stable subject acquired at 7 sites. RESULTS: The proposed count and the criterion standard count were highly correlated (r = 0.97, P <.001) and not significantly different (t59 = -.83, P =.41), and the variability of the proposed count across repeat scans was equivalent to that of lesion load. After accounting for lesion load and age, lesion count was negatively associated (t58 = - 2.73, P >.01) with the Expanded Disability Status Scale. Average lesion size had a higher association with the Expanded Disability Status Scale (r = 0.35, P >.01) than lesion load (r = 0.10, P =.44) or lesion count (r = -.12, P =.36) alone. CONCLUSIONS: This study introduces a novel technique for counting pathologically distinct lesions using cross-sectional data and demonstrates its ability to recover obscured longitudinal information. The proposed count allows more accurate estimation of lesion size, which correlated more closely with disability scores than either lesion load or lesion count alone.

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