An association of fibromyalgia with primary Sjogren's syndrome

A prospective study of 72 patients

R. P. Bonafede, D. C. Downey, Robert (Rob) Bennett

    Research output: Contribution to journalArticle

    83 Citations (Scopus)

    Abstract

    Objective. Fibromyalgia patients often describe the presence of dry-eyes and dry mouth. Conversely there is an increasing recognition that many patients with Sjogren's syndrome (SS) have fibromyalgia (FM). We decided to investigate this association. Methods. Seventy-two patients with FM were screened with a Schirmer's test. All patients with an abnormal test had a minor salivary gland biopsy. Results. Thirty-eight percent (n = 28) had a Schimer's test of <15 mm wetting at 5 minutes, however sicca symptoms were noted in only 19% of patients. Salivary gland biopsy in these 28 patients showed a focus score of ≥ 1 in 5; a positive antinuclear antibody test (ANA) was found in 4, a positive rheumatoid factor in 3 and anti-SSA SSB antibodies in 2. Another 8 patients had abnormal salivary gland lymphocytic foci, but there were 2; all 8 of these patients had a positive ANA. None of these patients have developed systemic features of SS over a 6 year period of follow up. Conclusion. There is a subgroup of patients presenting with FM who, on further testing, have findings consistent with primary SS. The prevalence of this association was 6.9% for probable SS and 11% for possible SS. These figures are probably an overestimation due to tertiary center referral bias. The etiologic and management implications of these observations are unclear.

    Original languageEnglish (US)
    Pages (from-to)133-136
    Number of pages4
    JournalJournal of Rheumatology
    Volume22
    Issue number1
    StatePublished - 1995

    Fingerprint

    Fibromyalgia
    Sjogren's Syndrome
    Prospective Studies
    Antinuclear Antibodies
    Salivary Glands
    Minor Salivary Glands
    Biopsy
    Rheumatoid Factor
    Tertiary Care Centers
    Mouth

    Keywords

    • Fibromyalgia
    • Minor salivary gland biopsy
    • Sjogren's syndrome

    ASJC Scopus subject areas

    • Immunology
    • Rheumatology

    Cite this

    An association of fibromyalgia with primary Sjogren's syndrome : A prospective study of 72 patients. / Bonafede, R. P.; Downey, D. C.; Bennett, Robert (Rob).

    In: Journal of Rheumatology, Vol. 22, No. 1, 1995, p. 133-136.

    Research output: Contribution to journalArticle

    Bonafede, R. P. ; Downey, D. C. ; Bennett, Robert (Rob). / An association of fibromyalgia with primary Sjogren's syndrome : A prospective study of 72 patients. In: Journal of Rheumatology. 1995 ; Vol. 22, No. 1. pp. 133-136.
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    abstract = "Objective. Fibromyalgia patients often describe the presence of dry-eyes and dry mouth. Conversely there is an increasing recognition that many patients with Sjogren's syndrome (SS) have fibromyalgia (FM). We decided to investigate this association. Methods. Seventy-two patients with FM were screened with a Schirmer's test. All patients with an abnormal test had a minor salivary gland biopsy. Results. Thirty-eight percent (n = 28) had a Schimer's test of <15 mm wetting at 5 minutes, however sicca symptoms were noted in only 19{\%} of patients. Salivary gland biopsy in these 28 patients showed a focus score of ≥ 1 in 5; a positive antinuclear antibody test (ANA) was found in 4, a positive rheumatoid factor in 3 and anti-SSA SSB antibodies in 2. Another 8 patients had abnormal salivary gland lymphocytic foci, but there were 2; all 8 of these patients had a positive ANA. None of these patients have developed systemic features of SS over a 6 year period of follow up. Conclusion. There is a subgroup of patients presenting with FM who, on further testing, have findings consistent with primary SS. The prevalence of this association was 6.9{\%} for probable SS and 11{\%} for possible SS. These figures are probably an overestimation due to tertiary center referral bias. The etiologic and management implications of these observations are unclear.",
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