An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse

Jonathan G. Crowston, Yu Xiang G Kong, Ian A. Trounce, Trung M. Dang, Eamonn T. Fahy, Bang V. Bui, John Morrison, Vicki Chrysostomou

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that induces reversible loss of inner retinal function associated with oxidative stress, glial cell activation and minimal loss of retinal ganglion cell (RGC) number. Young healthy mouse eyes recover inner retinal function within 7-days but more persistent functional loss is seen in older mice. Manipulation of diet and exercise further modify RGC recovery demonstrating the utility of this injury model for investigating lifestyle and therapeutic interventions. We believe that systematic investigation into the characteristics and determinants of RGC recovery following an IOP challenge will shed light on processes that govern RGC vulnerability in the early stages of glaucoma.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalExperimental Eye Research
Volume141
DOIs
Publication statusPublished - Dec 12 2014

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Keywords

  • Animal models
  • Electroretinography
  • Glaucoma
  • Intraocular pressure
  • Neurorecovery
  • Retinal ganglion cell

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Crowston, J. G., Kong, Y. X. G., Trounce, I. A., Dang, T. M., Fahy, E. T., Bui, B. V., ... Chrysostomou, V. (2014). An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse. Experimental Eye Research, 141, 3-8. https://doi.org/10.1016/j.exer.2015.03.006