Amyloid nephropathy

Mazdak Khalighi, W. Dean Wallace, Miguel F. Palma-Diaz

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Amyloidosis is an uncommon disease that is characterized by abnormal extracellular deposition of misfolded protein fibrils leading to organ dysfunction. The deposited proteins display common chemical and histologic properties but can vary dramatically in their origin. Kidney disease is a common manifestation in patients with systemic amyloidosis with a number of amyloidogenic proteins discovered in kidney biopsy specimens. The emergence of mass spectrometry-based proteomics has added to the diagnostic accuracy and overall understanding of amyloidosis. This in-depth review discusses the general histopathologic features of renal amyloidosis and includes an in-depth discussion of specific forms of amyloid affecting the kidney.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalClinical Kidney Journal
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Amyloidosis
Amyloid
Kidney
Amyloidogenic Proteins
Kidney Diseases
Proteomics
Mass Spectrometry
Proteins
Biopsy

Keywords

  • AA
  • AL
  • ALECT2
  • amyloidosis
  • hereditary amyloidosis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Khalighi, M., Dean Wallace, W., & Palma-Diaz, M. F. (2014). Amyloid nephropathy. Clinical Kidney Journal, 7(2), 97-106. https://doi.org/10.1093/ckj/sfu021

Amyloid nephropathy. / Khalighi, Mazdak; Dean Wallace, W.; Palma-Diaz, Miguel F.

In: Clinical Kidney Journal, Vol. 7, No. 2, 01.01.2014, p. 97-106.

Research output: Contribution to journalReview article

Khalighi, M, Dean Wallace, W & Palma-Diaz, MF 2014, 'Amyloid nephropathy', Clinical Kidney Journal, vol. 7, no. 2, pp. 97-106. https://doi.org/10.1093/ckj/sfu021
Khalighi M, Dean Wallace W, Palma-Diaz MF. Amyloid nephropathy. Clinical Kidney Journal. 2014 Jan 1;7(2):97-106. https://doi.org/10.1093/ckj/sfu021
Khalighi, Mazdak ; Dean Wallace, W. ; Palma-Diaz, Miguel F. / Amyloid nephropathy. In: Clinical Kidney Journal. 2014 ; Vol. 7, No. 2. pp. 97-106.
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