Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study

J. D. Pinter, W. E. Brown, S. Eliez, J. E. Schmitt, G. T. Capone, A. L. Reiss

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.

Original languageEnglish (US)
Pages (from-to)972-974
Number of pages3
JournalNeurology
Volume56
Issue number7
DOIs
StatePublished - Apr 10 2001

ASJC Scopus subject areas

  • Clinical Neurology

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