Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study

Joseph Pinter, W. E. Brown, S. Eliez, J. E. Schmitt, G. T. Capone, A. L. Reiss

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.

Original languageEnglish (US)
Pages (from-to)972-974
Number of pages3
JournalNeurology
Volume56
Issue number7
StatePublished - Apr 10 2001
Externally publishedYes

Fingerprint

Down Syndrome
Amygdala
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pinter, J., Brown, W. E., Eliez, S., Schmitt, J. E., Capone, G. T., & Reiss, A. L. (2001). Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study. Neurology, 56(7), 972-974.

Amygdala and hippocampal volumes in children with Down syndrome : A high-resolution MRI study. / Pinter, Joseph; Brown, W. E.; Eliez, S.; Schmitt, J. E.; Capone, G. T.; Reiss, A. L.

In: Neurology, Vol. 56, No. 7, 10.04.2001, p. 972-974.

Research output: Contribution to journalArticle

Pinter, J, Brown, WE, Eliez, S, Schmitt, JE, Capone, GT & Reiss, AL 2001, 'Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study', Neurology, vol. 56, no. 7, pp. 972-974.
Pinter J, Brown WE, Eliez S, Schmitt JE, Capone GT, Reiss AL. Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study. Neurology. 2001 Apr 10;56(7):972-974.
Pinter, Joseph ; Brown, W. E. ; Eliez, S. ; Schmitt, J. E. ; Capone, G. T. ; Reiss, A. L. / Amygdala and hippocampal volumes in children with Down syndrome : A high-resolution MRI study. In: Neurology. 2001 ; Vol. 56, No. 7. pp. 972-974.
@article{bea491bd9e5e4c04bf28c0add7db1ba3,
title = "Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study",
abstract = "The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.",
author = "Joseph Pinter and Brown, {W. E.} and S. Eliez and Schmitt, {J. E.} and Capone, {G. T.} and Reiss, {A. L.}",
year = "2001",
month = "4",
day = "10",
language = "English (US)",
volume = "56",
pages = "972--974",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Amygdala and hippocampal volumes in children with Down syndrome

T2 - A high-resolution MRI study

AU - Pinter, Joseph

AU - Brown, W. E.

AU - Eliez, S.

AU - Schmitt, J. E.

AU - Capone, G. T.

AU - Reiss, A. L.

PY - 2001/4/10

Y1 - 2001/4/10

N2 - The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.

AB - The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.

UR - http://www.scopus.com/inward/record.url?scp=0035836647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035836647&partnerID=8YFLogxK

M3 - Article

C2 - 11294940

AN - SCOPUS:0035836647

VL - 56

SP - 972

EP - 974

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 7

ER -