Amount and distribution of dietary protein affects clinical response to levodopa in parkinson’s disease

Julie Carter, John Nutt, William Woodward, L. F. Hatcher, T. L. Trotman

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Reducing dietary protein improves the effectiveness of levodopa (LD) but the most effective distribution of a low-protein diet (0.8 g/kg) is unclear. We compared a 1.6 g/kg protein diet, a 0.8 g/kg diet with protein evenly distributed between meals, and a 0.8 g/kg diet with protein restricted to the evening meal in 5 parkinsonian patients with motor fluctuations. We monitored clinical response, plasma LD, and plasma large amino acids (LNAAs) hourly throughout the day. Mean “on” times were 51% (1.6 g/kg diet), 67% (0.8 g/kg evenly distributed), and 77% (0.8 g/kg restricted). Hourly averages of plasma LD did not differ between the diets. The mean plasma LNAAs were 732 nmol/ml (l.6 g/kg diet), 640 (0.8 g/kg distributed), and 542 (0.8 g/kg restricted), and the diurnal pattern reflected the distribution of protein intake. In conclusion, the amount and distribution of dietary protein affect clinical response to LD. These effects are not related to LD absorption but are explained by the variation in plasma LNAAs.

Original languageEnglish (US)
Pages (from-to)552-556
Number of pages5
JournalNeurology
Volume39
Issue number4
StatePublished - 1989

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Dietary Proteins
Levodopa
Parkinson Disease
Diet
Protein-Restricted Diet
Meals
Proteins
Parkinson's Disease
Protein
Amino Acids
Plasma

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Amount and distribution of dietary protein affects clinical response to levodopa in parkinson’s disease. / Carter, Julie; Nutt, John; Woodward, William; Hatcher, L. F.; Trotman, T. L.

In: Neurology, Vol. 39, No. 4, 1989, p. 552-556.

Research output: Contribution to journalArticle

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