TY - JOUR
T1 - Aminoglycoside- and cisplatin-induced ototoxicity
T2 - Mechanisms and otoprotective strategies
AU - Kros, Corné J.
AU - Steyger, Peter S.
N1 - Funding Information:
This work was supported by MRC Programme Grant No. MR/K005561/1 (C.J.K.), and by NIHNIDCD Grant No. R01 DC004555 (P.S.S.). The illustrations were drafted by Karen Thiebes, Simplified Science Publishing. Funding agencies had no role in the preparation of this manuscript, or decision to publish.
Publisher Copyright:
© 2019 ColdSpring Harbor Laboratory Press; all rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a variety of environmental or occupational exposures (e.g., metals and solvents). This review provides a narrative derived from relevant papers describing factors contributing to (or increasing the risk of ) aminoglycoside and cisplatin-induced ototoxicity. We also review current strategies to protect against ototoxicity induced by these indispensable pharmacotherapeutic treatments for life-threatening infections and solid tumors. We end by highlighting several interventional strategies that are currently in development, as well as the diverse challenges that still need to be overcome to prevent drug-induced hearing loss.
AB - Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a variety of environmental or occupational exposures (e.g., metals and solvents). This review provides a narrative derived from relevant papers describing factors contributing to (or increasing the risk of ) aminoglycoside and cisplatin-induced ototoxicity. We also review current strategies to protect against ototoxicity induced by these indispensable pharmacotherapeutic treatments for life-threatening infections and solid tumors. We end by highlighting several interventional strategies that are currently in development, as well as the diverse challenges that still need to be overcome to prevent drug-induced hearing loss.
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U2 - 10.1101/cshperspect.a033548
DO - 10.1101/cshperspect.a033548
M3 - Article
C2 - 30559254
AN - SCOPUS:85074378179
SN - 2157-1422
VL - 9
JO - Cold Spring Harbor perspectives in medicine
JF - Cold Spring Harbor perspectives in medicine
IS - 11
M1 - a033548
ER -