Aminoglycoside- and cisplatin-induced ototoxicity: Mechanisms and otoprotective strategies

Corné J. Kros, Peter S. Steyger

Research output: Contribution to journalArticle

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Abstract

Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a variety of environmental or occupational exposures (e.g., metals and solvents). This review provides a narrative derived from relevant papers describing factors contributing to (or increasing the risk of ) aminoglycoside and cisplatin-induced ototoxicity. We also review current strategies to protect against ototoxicity induced by these indispensable pharmacotherapeutic treatments for life-threatening infections and solid tumors. We end by highlighting several interventional strategies that are currently in development, as well as the diverse challenges that still need to be overcome to prevent drug-induced hearing loss.

Original languageEnglish (US)
Article numbera033548
JournalCold Spring Harbor Perspectives in Medicine
Volume9
Issue number11
DOIs
StatePublished - Nov 2019

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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