Amikacin nephrotoxicity in the rat

Donald Houghton, C. E. Plamp, D. N. Gilbert, S. J. Kohlhepp, W. M. Bennett, G. A. Porter, J. DeFehr, M. Webb

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

When amikacin was administered to Fischer rats at a dose of 120 mg/kg/day for up to 14 days, renal proximal tubule cells became vacuolated, but BUN and creatinine remained normal. Renal cortical drug levels rose steadily throughout the treatment period. When, in a second trial of the same duration, the drug dose was tripled, focal proximal tubular necrosis, then regeneration, occurred and the animals became azotemic. Tissue drug concentrations peaked and began to decline during the treatment period, having reached levels more than three times higher than achieved at the lower dose. Ultrastructural changes were similar to those observed with other aminoglycosides. The results indicate that amikacin is less nephrotoxic than gentamicin and more toxic than tobramycin and netilmicin in the Fischer rat.

Original languageEnglish (US)
Pages (from-to)277-291
Number of pages15
JournalJournal of Environmental Pathology and Toxicology
Volume4
Issue number5-6
StatePublished - 1980

Fingerprint

Amikacin
Rats
Inbred F344 Rats
Pharmaceutical Preparations
Netilmicin
Proximal Kidney Tubule
Tobramycin
Poisons
Blood Urea Nitrogen
Aminoglycosides
Gentamicins
Regeneration
Creatinine
Animals
Necrosis
Tissue
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Houghton, D., Plamp, C. E., Gilbert, D. N., Kohlhepp, S. J., Bennett, W. M., Porter, G. A., ... Webb, M. (1980). Amikacin nephrotoxicity in the rat. Journal of Environmental Pathology and Toxicology, 4(5-6), 277-291.

Amikacin nephrotoxicity in the rat. / Houghton, Donald; Plamp, C. E.; Gilbert, D. N.; Kohlhepp, S. J.; Bennett, W. M.; Porter, G. A.; DeFehr, J.; Webb, M.

In: Journal of Environmental Pathology and Toxicology, Vol. 4, No. 5-6, 1980, p. 277-291.

Research output: Contribution to journalArticle

Houghton, D, Plamp, CE, Gilbert, DN, Kohlhepp, SJ, Bennett, WM, Porter, GA, DeFehr, J & Webb, M 1980, 'Amikacin nephrotoxicity in the rat', Journal of Environmental Pathology and Toxicology, vol. 4, no. 5-6, pp. 277-291.
Houghton D, Plamp CE, Gilbert DN, Kohlhepp SJ, Bennett WM, Porter GA et al. Amikacin nephrotoxicity in the rat. Journal of Environmental Pathology and Toxicology. 1980;4(5-6):277-291.
Houghton, Donald ; Plamp, C. E. ; Gilbert, D. N. ; Kohlhepp, S. J. ; Bennett, W. M. ; Porter, G. A. ; DeFehr, J. ; Webb, M. / Amikacin nephrotoxicity in the rat. In: Journal of Environmental Pathology and Toxicology. 1980 ; Vol. 4, No. 5-6. pp. 277-291.
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