Alterations in non-type I collagen biomarkers in osteogenesis imperfecta

Lindsey Nicol, Patrick Morar, Ying Wang, Kim Henriksen, Shu Sun, Morten Karsdal, Rosamund Smith, Sandesh C.S. Nagamani, Jay Shapiro, Brendan Lee, Eric Orwoll

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Osteogenesis imperfecta [1] is a rare disorder of connective tissue caused by abnormalities in the synthesis or processing of type I collagen. Type I collagen is the most abundant type of collagen and is expressed in almost all connective tissues. Given that type I collagen interacts with other collagens based in the extracellular matrix (ECM), we hypothesized changes in type I collagen in OI would result in perturbations in the homeostasis of other collagen types. We measured serum biomarkers of several non-type I collagens in patients with mild (type I) and moderate-to-severe (type III/IV) OI. Compared to controls, those with moderate-to severe OI had a higher mean level of the synthesis markers of collagen III (ProC3) (P = 0.02), and levels of collagen V (ProC5) (P = 0.07) were slightly, but not significantly, higher. Degradation markers of collage type IV (C4M2) (P = 0.04) and type VI (C6M) (P = 0.003) were also higher. In each case, a test for trend suggested levels were higher in moderate-to-severe OI, intermediate in mild OI, and lowest in controls (P = 0.06–0.002). These changes supports the hypothesis that mutations in type I collagen induce a widespread alteration in the ECM, and that the diverse clinical manifestations of OI reflect an extensive disruption in ECM biology.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalBone
Volume120
DOIs
StatePublished - Mar 1 2019

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Keywords

  • Collagen type I
  • Collagen type III
  • Collagen type IV
  • Collagen type V
  • Collagen type VI
  • Collagen type VII
  • Extracellular matrix
  • Osteogenesis imperfecta

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Nicol, L., Morar, P., Wang, Y., Henriksen, K., Sun, S., Karsdal, M., Smith, R., Nagamani, S. C. S., Shapiro, J., Lee, B., & Orwoll, E. (2019). Alterations in non-type I collagen biomarkers in osteogenesis imperfecta. Bone, 120, 70-74. https://doi.org/10.1016/j.bone.2018.09.024