Alterations in non-type I collagen biomarkers in osteogenesis imperfecta

Lindsey Nicol, Patrick Morar, Ying Wang, Kim Henriksen, Shu Sun, Morten Karsdal, Rosamund Smith, Sandesh C.S. Nagamani, Jay Shapiro, Brendan Lee, Eric Orwoll

Research output: Contribution to journalArticle

Abstract

Osteogenesis imperfecta [1] is a rare disorder of connective tissue caused by abnormalities in the synthesis or processing of type I collagen. Type I collagen is the most abundant type of collagen and is expressed in almost all connective tissues. Given that type I collagen interacts with other collagens based in the extracellular matrix (ECM), we hypothesized changes in type I collagen in OI would result in perturbations in the homeostasis of other collagen types. We measured serum biomarkers of several non-type I collagens in patients with mild (type I) and moderate-to-severe (type III/IV) OI. Compared to controls, those with moderate-to severe OI had a higher mean level of the synthesis markers of collagen III (ProC3) (P = 0.02), and levels of collagen V (ProC5) (P = 0.07) were slightly, but not significantly, higher. Degradation markers of collage type IV (C4M2) (P = 0.04) and type VI (C6M) (P = 0.003) were also higher. In each case, a test for trend suggested levels were higher in moderate-to-severe OI, intermediate in mild OI, and lowest in controls (P = 0.06–0.002). These changes supports the hypothesis that mutations in type I collagen induce a widespread alteration in the ECM, and that the diverse clinical manifestations of OI reflect an extensive disruption in ECM biology.

LanguageEnglish (US)
Pages70-74
Number of pages5
JournalBone
Volume120
DOIs
StatePublished - Mar 1 2019

Fingerprint

Osteogenesis Imperfecta
Collagen Type I
Collagen
Biomarkers
Extracellular Matrix
Connective Tissue
Homeostasis
Mutation
Serum

Keywords

  • Collagen type I
  • Collagen type III
  • Collagen type IV
  • Collagen type V
  • Collagen type VI
  • Collagen type VII
  • Extracellular matrix
  • Osteogenesis imperfecta

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Nicol, L., Morar, P., Wang, Y., Henriksen, K., Sun, S., Karsdal, M., ... Orwoll, E. (2019). Alterations in non-type I collagen biomarkers in osteogenesis imperfecta. Bone, 120, 70-74. https://doi.org/10.1016/j.bone.2018.09.024

Alterations in non-type I collagen biomarkers in osteogenesis imperfecta. / Nicol, Lindsey; Morar, Patrick; Wang, Ying; Henriksen, Kim; Sun, Shu; Karsdal, Morten; Smith, Rosamund; Nagamani, Sandesh C.S.; Shapiro, Jay; Lee, Brendan; Orwoll, Eric.

In: Bone, Vol. 120, 01.03.2019, p. 70-74.

Research output: Contribution to journalArticle

Nicol, L, Morar, P, Wang, Y, Henriksen, K, Sun, S, Karsdal, M, Smith, R, Nagamani, SCS, Shapiro, J, Lee, B & Orwoll, E 2019, 'Alterations in non-type I collagen biomarkers in osteogenesis imperfecta' Bone, vol. 120, pp. 70-74. https://doi.org/10.1016/j.bone.2018.09.024
Nicol L, Morar P, Wang Y, Henriksen K, Sun S, Karsdal M et al. Alterations in non-type I collagen biomarkers in osteogenesis imperfecta. Bone. 2019 Mar 1;120:70-74. https://doi.org/10.1016/j.bone.2018.09.024
Nicol, Lindsey ; Morar, Patrick ; Wang, Ying ; Henriksen, Kim ; Sun, Shu ; Karsdal, Morten ; Smith, Rosamund ; Nagamani, Sandesh C.S. ; Shapiro, Jay ; Lee, Brendan ; Orwoll, Eric. / Alterations in non-type I collagen biomarkers in osteogenesis imperfecta. In: Bone. 2019 ; Vol. 120. pp. 70-74.
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