Alkalization to retard progression of chronic kidney disease

Nimrit Goraya, Kalani L. Raphael, Donald E. Wesson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Progression of chronic kidney disease (CKD) contributes to increasing end-stage kidney disease and so addressing factors that mediate CKD progression is an important investigative focus. Evolving studies support a spectrum of “acid (H+) stress” beyond metabolic acidosis that includes pathologic acid (H+) accumulation without changes in plasma acid–base parameters reflective of metabolic acidosis. The full spectrum of H+ stress prior to its manifestation as metabolic acidosis appears to cause kidney injury and progressive CKD. Recent studies support that alkali therapy done with diet and/or pharmacologically ameliorates H+ stress and retards CKD progression. This chapter discusses potential mechanisms for H+ stress–induced CKD progression and strategies by which clinicians can execute such alkali therapy.

Original languageEnglish (US)
Title of host publicationNutritional Management of Renal Disease, Fourth Edition
PublisherElsevier
Pages297-309
Number of pages13
ISBN (Electronic)9780128185407
ISBN (Print)9780128185414
DOIs
StatePublished - Jan 1 2021

Keywords

  • Acid
  • acidosis
  • alkali
  • bicarbonate
  • chronic kidney disease
  • diet
  • GFR

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

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