Airway Sensory Nerve Plasticity in Asthma and Chronic Cough

Matthew G. Drake, Madeline Cook, Allison D. Fryer, David B. Jacoby, Gregory D. Scott

Research output: Contribution to journalReview articlepeer-review

Abstract

Airway sensory nerves detect a wide variety of chemical and mechanical stimuli, and relay signals to circuits within the brainstem that regulate breathing, cough, and bronchoconstriction. Recent advances in histological methods, single cell PCR analysis and transgenic mouse models have illuminated a remarkable degree of sensory nerve heterogeneity and have enabled an unprecedented ability to test the functional role of specific neuronal populations in healthy and diseased lungs. This review focuses on how neuronal plasticity contributes to development of two of the most common airway diseases, asthma and chronic cough, and discusses the therapeutic implications of emerging treatments that target airway sensory nerves.

Original languageEnglish (US)
Article number720538
JournalFrontiers in Physiology
Volume12
DOIs
StatePublished - Sep 7 2021

Keywords

  • asthma
  • cough
  • eosinophil
  • nerve
  • neurokinin
  • neurotrophin
  • P2X3

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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