TY - JOUR
T1 - Air pollution as a risk factor for type 2 diabetes
AU - Rao, Xiaoquan
AU - Patel, Priti
AU - Puett, Robin
AU - Rajagopalan, Sanjay
N1 - Funding Information:
EPA grant (RD83479701) and NIH grants (RO-1ES015146, RO-1ES017290, and RO-1ES019616 to S.R.); partially supported by grant R01ES019168 from the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) (to R.P.). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIEHS, NIH.
Publisher Copyright:
© The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Recent studies in both humans and animals suggest that air pollution is an important risk factor for type 2 diabetes mellitus (T2DM). However, the mechanism by which air pollution mediates propensity to diabetes is not fully understood. While a number of epidemiologic studies have shown a positive association between ambient air pollution exposure and risk for T2DM, some studies have not found such a relationship. Experimental studies in susceptible disease models do support this association and suggest the involvement of tissues involved in the pathogenesis of T2DM such as the immune system, adipose, liver, and central nervous system. This review summarizes the epidemiologic and experimental evidence between ambient outdoor air pollution and T2DM.
AB - Recent studies in both humans and animals suggest that air pollution is an important risk factor for type 2 diabetes mellitus (T2DM). However, the mechanism by which air pollution mediates propensity to diabetes is not fully understood. While a number of epidemiologic studies have shown a positive association between ambient air pollution exposure and risk for T2DM, some studies have not found such a relationship. Experimental studies in susceptible disease models do support this association and suggest the involvement of tissues involved in the pathogenesis of T2DM such as the immune system, adipose, liver, and central nervous system. This review summarizes the epidemiologic and experimental evidence between ambient outdoor air pollution and T2DM.
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U2 - 10.1093/toxsci/kfu250
DO - 10.1093/toxsci/kfu250
M3 - Article
C2 - 25628401
AN - SCOPUS:84924667635
SN - 1096-6080
VL - 143
SP - 231
EP - 241
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 2
ER -