Age-related changes of vasopressin content of microdissected areas of the rat brain

Daniel Dorsa, Lucy Bottemiller

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Vasopressin contents of posterior pituitaries and intra- and extrahypothalamic nuclei of brains from 3-month and 24-month-old Long-Evans rats and from Brattleboro rats heterozygous (HEDI) and homozygous (HODI) for diabetes insipidus were measured by radioimmunoassay. The pituitary content of vasopressin was highest in young rats and was significantly lower in HEDI tissue. The peptide was not detected in HODI pituitaries. In the brain regions studied both aged and HEDI rats showed reduced vasopressin contents as compared to young animals. In light of evidence of memory deficiencies in both HEDI and HODI rats, the possibility arises that memory decrements associated with senescence may be related to altered vasopressin synthesis and/or secretion occurring with aging of these neuronal systems.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalBrain Research
Volume242
Issue number1
DOIs
StatePublished - Jun 17 1982
Externally publishedYes

Fingerprint

Vasopressins
Brain
Brattleboro Rats
Long Evans Rats
Diabetes Insipidus
Radioimmunoassay
Peptides

Keywords

  • aging
  • brain nuclei
  • Brattleboro rats
  • radioimmunoassay
  • vasopressin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Age-related changes of vasopressin content of microdissected areas of the rat brain. / Dorsa, Daniel; Bottemiller, Lucy.

In: Brain Research, Vol. 242, No. 1, 17.06.1982, p. 151-156.

Research output: Contribution to journalArticle

@article{b4691baf7c074f018d436ffa0083acfc,
title = "Age-related changes of vasopressin content of microdissected areas of the rat brain",
abstract = "Vasopressin contents of posterior pituitaries and intra- and extrahypothalamic nuclei of brains from 3-month and 24-month-old Long-Evans rats and from Brattleboro rats heterozygous (HEDI) and homozygous (HODI) for diabetes insipidus were measured by radioimmunoassay. The pituitary content of vasopressin was highest in young rats and was significantly lower in HEDI tissue. The peptide was not detected in HODI pituitaries. In the brain regions studied both aged and HEDI rats showed reduced vasopressin contents as compared to young animals. In light of evidence of memory deficiencies in both HEDI and HODI rats, the possibility arises that memory decrements associated with senescence may be related to altered vasopressin synthesis and/or secretion occurring with aging of these neuronal systems.",
keywords = "aging, brain nuclei, Brattleboro rats, radioimmunoassay, vasopressin",
author = "Daniel Dorsa and Lucy Bottemiller",
year = "1982",
month = "6",
day = "17",
doi = "10.1016/0006-8993(82)90505-4",
language = "English (US)",
volume = "242",
pages = "151--156",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Age-related changes of vasopressin content of microdissected areas of the rat brain

AU - Dorsa, Daniel

AU - Bottemiller, Lucy

PY - 1982/6/17

Y1 - 1982/6/17

N2 - Vasopressin contents of posterior pituitaries and intra- and extrahypothalamic nuclei of brains from 3-month and 24-month-old Long-Evans rats and from Brattleboro rats heterozygous (HEDI) and homozygous (HODI) for diabetes insipidus were measured by radioimmunoassay. The pituitary content of vasopressin was highest in young rats and was significantly lower in HEDI tissue. The peptide was not detected in HODI pituitaries. In the brain regions studied both aged and HEDI rats showed reduced vasopressin contents as compared to young animals. In light of evidence of memory deficiencies in both HEDI and HODI rats, the possibility arises that memory decrements associated with senescence may be related to altered vasopressin synthesis and/or secretion occurring with aging of these neuronal systems.

AB - Vasopressin contents of posterior pituitaries and intra- and extrahypothalamic nuclei of brains from 3-month and 24-month-old Long-Evans rats and from Brattleboro rats heterozygous (HEDI) and homozygous (HODI) for diabetes insipidus were measured by radioimmunoassay. The pituitary content of vasopressin was highest in young rats and was significantly lower in HEDI tissue. The peptide was not detected in HODI pituitaries. In the brain regions studied both aged and HEDI rats showed reduced vasopressin contents as compared to young animals. In light of evidence of memory deficiencies in both HEDI and HODI rats, the possibility arises that memory decrements associated with senescence may be related to altered vasopressin synthesis and/or secretion occurring with aging of these neuronal systems.

KW - aging

KW - brain nuclei

KW - Brattleboro rats

KW - radioimmunoassay

KW - vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0019949817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019949817&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(82)90505-4

DO - 10.1016/0006-8993(82)90505-4

M3 - Article

C2 - 7104725

AN - SCOPUS:0019949817

VL - 242

SP - 151

EP - 156

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -