Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice

Jules B. Panksepp, Kimberly A. Jochman, Joseph U. Kim, Jamie K. Koy, Ellie D. Wilson, Qiliang Chen, Clarinda R. Wilson, Garet Lahvis

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Social approach is crucial for establishing relationships among individuals. In rodents, social approach has been studied primarily within the context of behavioral phenomena related to sexual reproduction, such as mating, territory defense and parental care. However, many forms of social interaction occur before the onset of reproductive maturity, which suggests that some processes underlying social approach among juvenile animals are probably distinct from those in adults. We conducted a longitudinal study of social investigation (SI) in mice from two inbred strains to assess the extent to which genetic factors influence the motivation for young mice to approach one another. Early-adolescent C57BL/6J (B6) mice, tested 4-6 days after weaning, investigated former cage mates to a greater degree than BALB/cJ (BALB) mice, irrespective of the sex composition within an interacting pair. This strain difference was not due to variation in maternal care, the phenotypic characteristics of stimulus mice or sensitivity to the length of isolation prior to testing, nor was it attributable to a general difference in appetitive motivation. Ultrasonic vocalization (USV) production was positively correlated with the SI responses of mice from both strains. Interestingly, several USV characteristics segregated with the genetic background of young mice, including a higher average frequency and shorter duration for the USVs emitted by B6 mice. An assessment of conditioned place preference responses indicated that there was a strain-dependent difference in the rewarding nature of social contact. As adolescent mice aged, SI responses gradually became less sensitive to genetic background and more responsive to the particular sex of individuals within an interacting pair. We have thus identified a specific, genetic influence on the motivation of early-adolescent mice to approach one another. Consistent with classical theories of motivation, which propose a functional relationship between behavioral approach and reward, our findings indicate that reward is a proximal mechanism through which genetic factors affect social motivation during early adolescence.

Original languageEnglish (US)
Article numbere351
JournalPLoS One
Volume2
Issue number4
DOIs
StatePublished - Apr 4 2007
Externally publishedYes

Fingerprint

Reward
Ultrasonics
animal communication
ultrasonics
Communication
genetic variation
mice
Motivation
vocalization
genetic background
Animals
adolescence
Inbred Strains Mice
Interpersonal Relations
gender
strain differences
Weaning
Testing
longitudinal studies
sexual reproduction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice. / Panksepp, Jules B.; Jochman, Kimberly A.; Kim, Joseph U.; Koy, Jamie K.; Wilson, Ellie D.; Chen, Qiliang; Wilson, Clarinda R.; Lahvis, Garet.

In: PLoS One, Vol. 2, No. 4, e351, 04.04.2007.

Research output: Contribution to journalArticle

Panksepp, Jules B. ; Jochman, Kimberly A. ; Kim, Joseph U. ; Koy, Jamie K. ; Wilson, Ellie D. ; Chen, Qiliang ; Wilson, Clarinda R. ; Lahvis, Garet. / Affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice. In: PLoS One. 2007 ; Vol. 2, No. 4.
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