Advanced squamous cell carcinoma of the maxillary sinus. Results of combined regional infusion chemotherapy, radiation therapy and surgery

H. Stephens Moseley, Larry R. Thomas, Edwin C. Everts, Kenneth R. Stevens, Karen M. Ireland

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Sequential intraarterial chemotherapy using bleomycin and methotrexate followed by high dose radiation and surgery was evaluated in 10 patients with stage III and IV squamous carcinomas of the maxillary sinus. Seven of 10 patients had extensive tumor necrosis in the surgical specimen, and no evidence of residual tumor was found in 4 of these patients. After a median follow up period of 24 months, there has been only one local recurrence in resected patients. Three patients died from pulmonary metastases. Although many unanswered questions remain regarding the efficacy of triple therapy for maxillary sinus malignancy, these results are encouraging and establish that surgical resection and healing are not compromised by preoperative chemotherapy and radiation.

Original languageEnglish (US)
Pages (from-to)522-525
Number of pages4
JournalThe American Journal of Surgery
Volume141
Issue number5
DOIs
StatePublished - May 1981

ASJC Scopus subject areas

  • Surgery

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